The effect of RAI2 on colorectal cancer cell xenograft mice. a, b Representative pictures of xenograft tumors from RAI2-unexpressed (upper) and re-expressed RKO cells (lower). c Subcutaneous tumor growth curves in xenograft mice with or without RAI2 re-expression (**P < 0.01). d Histogram represents the average weight of xenograft tumors in RAI2 unexpressed and re-expressed groups (***P < 0.001). e IHC staining reveals the expression levels of RAI2, MMP2, and MMP7 in RAI2-unexpressed and RAI2 re-expressed-RKO cell xenografts (× 400). The expression scores are shown below as scatterplots (***P < 0.001).