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Table 3 BCAT1 and IKZF1 methylation in 91 cancer tissue samples according to case demographics and tumour characteristics

From: Circulating tumour DNA for monitoring colorectal cancer—a prospective cohort study to assess relationship to tissue methylation, cancer characteristics and surgical resection

    %Methylation, median (IQR)
Variable factor Category N BCAT1 P IKZF1 P
Age < 65 32 35.8 (14–57.5) 0.0391 52.5 (11.4–69.7) 0.1431
≥ 65 59 50.1 (31.4–67.8) 64.8 (31.3–96.3)
Gender Female 45 46.9 (31.0–60.7) 0.4441 59 (41.6–96.3) 0.3591
Male 46 42.2 (26.9–63.1) 59.3 (10.7–83.3)
Stage I 19 50.1 (19.8–81.3) 0.5812 56.9 (9.1–115.6) 0.6592
II 34 44.6 (20.2–58.9) 48.7 (0.5–82)
III 29 43.3 (32.9–51.9) 61.1 (42.6–84.7)
IV 9 57.7 (36.1–71.4) 54.3 (41.4–98.7)
T stage T1 8 68.6 (54.4–93.0) 0.0662 88.7 (34.4–132.4) 0.3622
T2 13 27.5 (18.8–51.4) 32.1 (9.1–100.3)
T3 48 50.5 (32.7–60.0) 65.1 (31.8–84.0)
T4 22 32.6 (23.6–52.9) 42.1 (10.7–69.0)
N stage N0 57 50.9 (26.9–63.3) 0.6802 63.4 (15.8–97.8) 0.5382
N1/N2 33 43.3 (30.3–59.4) 59 (41.4–76.1)
Nx 1 26.9 (26.9–26.9) 9.1 (9.1–9.1)
M stage M0 79 44.8 (26.9–63.1) 0.2822 60.8 (18.5–91) 0.7852
M1 9 57.7 (36.1–71.4) 54.3 (41.4–98.7)
Mx 3 31.7 (18.8–35.4) 50.3 (0.0–85.5)
Size (mm) < 20 mm 4 59.6 (34.9–103.7) 0.5512 68.5 (14.3–152.9) 0.8562
20–50 mm 52 41.5 (27.9–57) 57 (16.2–88.3)
> 50 mm 34 47.8 (23.6–67.8) 62.1 (28–84.7)
Unknown 1 81.3 (81.3–81.3) 68.8 (68.8–68.8)
Location Proximal 50 51.6 (31.0–67.3) 0.0291 68.9 (41.6–98.7) 0.0551
Distal 41 37.9 (19.8–51.9) 41.4 (16.6–68.8)
Lymphatic invasion Yes 25 42.2 (33.9–63.1) 0.6501 63.4 (40.8–85.5) 0.8271
No 66 48.3 (26.9–58.9) 57 (18.5–91)
Perineural invasion Yes 13 37.9 (19.9–56.4) 0.6261 41.4 (10.7–84.7) 0.7081
No 78 48.3 (27.4–63.1) 59.9 (28.5–96.1)
Extramural vascular invasion Yes 4 42.0 (32.2–67.2) 0.8161 56.8 (24.6–102.3) 0.8161
No 87 44.8 (26.9–63.1) 59.0 (18.5–91.0)
Intramural vascular invasion Yes 1 28.3 (28.3–28.3) 0.4461 41.2 (41.2–41.2) 0.5941
No 90 45.8 (26.9–63.1) 59.9 (18.5–91.0)
Differentiation Poor 26 47.4 (30.3–67.8) 0.3202 59.9 (32.6–96.3) 0.6912
Moderate 53 44.8 (26.9–58.9) 57.1 (12.0–83.3)
Well 7 36.1 (19.8–39) 48.7 (18.5–70.6)
Unknown 5 56.2 (51.4–63.3) 81.2 (76.3–84.7)
  1. 1Mann-Whitney test on medians (two-tailed)
  2. 2Kruskal-Wallis test on medians (two-tailed)