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Table 3 BCAT1 and IKZF1 methylation in 91 cancer tissue samples according to case demographics and tumour characteristics

From: Circulating tumour DNA for monitoring colorectal cancer—a prospective cohort study to assess relationship to tissue methylation, cancer characteristics and surgical resection

   

%Methylation, median (IQR)

Variable factor

Category

N

BCAT1

P

IKZF1

P

Age

< 65

32

35.8 (14–57.5)

0.0391

52.5 (11.4–69.7)

0.1431

≥ 65

59

50.1 (31.4–67.8)

64.8 (31.3–96.3)

Gender

Female

45

46.9 (31.0–60.7)

0.4441

59 (41.6–96.3)

0.3591

Male

46

42.2 (26.9–63.1)

59.3 (10.7–83.3)

Stage

I

19

50.1 (19.8–81.3)

0.5812

56.9 (9.1–115.6)

0.6592

II

34

44.6 (20.2–58.9)

48.7 (0.5–82)

III

29

43.3 (32.9–51.9)

61.1 (42.6–84.7)

IV

9

57.7 (36.1–71.4)

54.3 (41.4–98.7)

T stage

T1

8

68.6 (54.4–93.0)

0.0662

88.7 (34.4–132.4)

0.3622

T2

13

27.5 (18.8–51.4)

32.1 (9.1–100.3)

T3

48

50.5 (32.7–60.0)

65.1 (31.8–84.0)

T4

22

32.6 (23.6–52.9)

42.1 (10.7–69.0)

N stage

N0

57

50.9 (26.9–63.3)

0.6802

63.4 (15.8–97.8)

0.5382

N1/N2

33

43.3 (30.3–59.4)

59 (41.4–76.1)

Nx

1

26.9 (26.9–26.9)

9.1 (9.1–9.1)

M stage

M0

79

44.8 (26.9–63.1)

0.2822

60.8 (18.5–91)

0.7852

M1

9

57.7 (36.1–71.4)

54.3 (41.4–98.7)

Mx

3

31.7 (18.8–35.4)

50.3 (0.0–85.5)

Size (mm)

< 20 mm

4

59.6 (34.9–103.7)

0.5512

68.5 (14.3–152.9)

0.8562

20–50 mm

52

41.5 (27.9–57)

57 (16.2–88.3)

> 50 mm

34

47.8 (23.6–67.8)

62.1 (28–84.7)

Unknown

1

81.3 (81.3–81.3)

68.8 (68.8–68.8)

Location

Proximal

50

51.6 (31.0–67.3)

0.0291

68.9 (41.6–98.7)

0.0551

Distal

41

37.9 (19.8–51.9)

41.4 (16.6–68.8)

Lymphatic invasion

Yes

25

42.2 (33.9–63.1)

0.6501

63.4 (40.8–85.5)

0.8271

No

66

48.3 (26.9–58.9)

57 (18.5–91)

Perineural invasion

Yes

13

37.9 (19.9–56.4)

0.6261

41.4 (10.7–84.7)

0.7081

No

78

48.3 (27.4–63.1)

59.9 (28.5–96.1)

Extramural vascular invasion

Yes

4

42.0 (32.2–67.2)

0.8161

56.8 (24.6–102.3)

0.8161

No

87

44.8 (26.9–63.1)

59.0 (18.5–91.0)

Intramural vascular invasion

Yes

1

28.3 (28.3–28.3)

0.4461

41.2 (41.2–41.2)

0.5941

No

90

45.8 (26.9–63.1)

59.9 (18.5–91.0)

Differentiation

Poor

26

47.4 (30.3–67.8)

0.3202

59.9 (32.6–96.3)

0.6912

Moderate

53

44.8 (26.9–58.9)

57.1 (12.0–83.3)

Well

7

36.1 (19.8–39)

48.7 (18.5–70.6)

Unknown

5

56.2 (51.4–63.3)

81.2 (76.3–84.7)

  1. 1Mann-Whitney test on medians (two-tailed)
  2. 2Kruskal-Wallis test on medians (two-tailed)