| | | |
%Methylation, median (IQR)
|
|---|
|
Variable factor
|
Category
|
N
|
BCAT1
|
P
|
IKZF1
|
P
|
|---|
|
Age
|
< 65
|
32
|
35.8 (14–57.5)
|
0.0391
|
52.5 (11.4–69.7)
|
0.1431
|
|
≥ 65
|
59
|
50.1 (31.4–67.8)
|
64.8 (31.3–96.3)
|
|
Gender
|
Female
|
45
|
46.9 (31.0–60.7)
|
0.4441
|
59 (41.6–96.3)
|
0.3591
|
|
Male
|
46
|
42.2 (26.9–63.1)
|
59.3 (10.7–83.3)
|
|
Stage
|
I
|
19
|
50.1 (19.8–81.3)
|
0.5812
|
56.9 (9.1–115.6)
|
0.6592
|
|
II
|
34
|
44.6 (20.2–58.9)
|
48.7 (0.5–82)
|
|
III
|
29
|
43.3 (32.9–51.9)
|
61.1 (42.6–84.7)
|
|
IV
|
9
|
57.7 (36.1–71.4)
|
54.3 (41.4–98.7)
|
|
T stage
|
T1
|
8
|
68.6 (54.4–93.0)
|
0.0662
|
88.7 (34.4–132.4)
|
0.3622
|
|
T2
|
13
|
27.5 (18.8–51.4)
|
32.1 (9.1–100.3)
|
|
T3
|
48
|
50.5 (32.7–60.0)
|
65.1 (31.8–84.0)
|
|
T4
|
22
|
32.6 (23.6–52.9)
|
42.1 (10.7–69.0)
|
|
N stage
|
N0
|
57
|
50.9 (26.9–63.3)
|
0.6802
|
63.4 (15.8–97.8)
|
0.5382
|
|
N1/N2
|
33
|
43.3 (30.3–59.4)
|
59 (41.4–76.1)
|
|
Nx
|
1
|
26.9 (26.9–26.9)
|
9.1 (9.1–9.1)
|
|
M stage
|
M0
|
79
|
44.8 (26.9–63.1)
|
0.2822
|
60.8 (18.5–91)
|
0.7852
|
|
M1
|
9
|
57.7 (36.1–71.4)
|
54.3 (41.4–98.7)
|
|
Mx
|
3
|
31.7 (18.8–35.4)
|
50.3 (0.0–85.5)
|
|
Size (mm)
|
< 20 mm
|
4
|
59.6 (34.9–103.7)
|
0.5512
|
68.5 (14.3–152.9)
|
0.8562
|
|
20–50 mm
|
52
|
41.5 (27.9–57)
|
57 (16.2–88.3)
|
|
> 50 mm
|
34
|
47.8 (23.6–67.8)
|
62.1 (28–84.7)
|
|
Unknown
|
1
|
81.3 (81.3–81.3)
|
68.8 (68.8–68.8)
|
|
Location
|
Proximal
|
50
|
51.6 (31.0–67.3)
|
0.0291
|
68.9 (41.6–98.7)
|
0.0551
|
|
Distal
|
41
|
37.9 (19.8–51.9)
|
41.4 (16.6–68.8)
|
|
Lymphatic invasion
|
Yes
|
25
|
42.2 (33.9–63.1)
|
0.6501
|
63.4 (40.8–85.5)
|
0.8271
|
|
No
|
66
|
48.3 (26.9–58.9)
|
57 (18.5–91)
|
|
Perineural invasion
|
Yes
|
13
|
37.9 (19.9–56.4)
|
0.6261
|
41.4 (10.7–84.7)
|
0.7081
|
|
No
|
78
|
48.3 (27.4–63.1)
|
59.9 (28.5–96.1)
|
|
Extramural vascular invasion
|
Yes
|
4
|
42.0 (32.2–67.2)
|
0.8161
|
56.8 (24.6–102.3)
|
0.8161
|
|
No
|
87
|
44.8 (26.9–63.1)
|
59.0 (18.5–91.0)
|
|
Intramural vascular invasion
|
Yes
|
1
|
28.3 (28.3–28.3)
|
0.4461
|
41.2 (41.2–41.2)
|
0.5941
|
|
No
|
90
|
45.8 (26.9–63.1)
|
59.9 (18.5–91.0)
|
|
Differentiation
|
Poor
|
26
|
47.4 (30.3–67.8)
|
0.3202
|
59.9 (32.6–96.3)
|
0.6912
|
|
Moderate
|
53
|
44.8 (26.9–58.9)
|
57.1 (12.0–83.3)
|
|
Well
|
7
|
36.1 (19.8–39)
|
48.7 (18.5–70.6)
|
|
Unknown
|
5
|
56.2 (51.4–63.3)
|
81.2 (76.3–84.7)
|
- 1Mann-Whitney test on medians (two-tailed)
- 2Kruskal-Wallis test on medians (two-tailed)
