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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Genome-wide analysis of DNA methylation in bronchial washings

Fig. 2

Comparison of the most highly methylated CpGs between TCGA cohort and bronchial washings. a Statistical significances of top 18,000 CpGs discovered from the TCGA cohort were compared to those of top 600 CpGs from bronchial washing (N = 123). The number of differentially methylated CpGs was significantly higher in the TCGA cohort than that in bronchial washings. be Hundreds of genes were found to be significantly methylated in the TCGA cohort only. Methylation levels of representative genes important in the pathogenesis of NSCLC were compared between the TCGA cohort and bronchial washings: CpGs in ITGA8 (b), DLK1 (c), HTR1B (d), and RSPO2 (e) genes were significantly methylated (p < 1.0E−07) in the TCGA cohort. The Y-axis represents β values

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