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Table 2 The relationships between methylation status at 2 months and pre- and postnatal environments

From: Postnatal relative adrenal insufficiency results in methylation of the glucocorticoid receptor gene in preterm infants: a retrospective cohort study

CpG no.

2

3

4

5

8

9

10

11

Gc circ

0.568

0.877

0.968

0.754

0.715

0.855

0.66

 

SD

− 0.547

     

− 0.352

 

Gc CLD

− 0.365

   

0.327

   

AS

− 0.193

   

− 0.298

− 0.254

  

Bf

       

− 0.492

Adjusted R2

0.922

0.774

0.933

0.544

0.752

0.858

0.724

0.198

Overall p

※

※

※

※

※

※

※

0.032

CpG no.

12

15

16

17

18

19

23

24

Gc circ

0.802

0.789

0.837

0.755

0.887

0.842

0.894

0.639

SD

 

− 0.255

− 0.234

− 0.285

   

− 0.364

Gc CLD

        

Bf

        

Adjusted R2

0.623

0.838

0.909

0.811

0.89

0.691

0.788

0.702

Overall p

※

※

※

※

※

※

※

※

CpG no.

25

26

31

32

33

34

36

39

Gc circ

0.81

0.865

0.908

0.877

0.892

0.902

 

0.827

SD

− 0.246

       

Gc CLD

        

AS

        

Bf

      

− 0.506

 

Adjusted R2

0.869

0.734

0.814

0.756

0.784

0.803

0.213

0.665

Overall p

※

※

※

※

※

※

0.027

※

  1. Regression coefficients of independent variables are shown. A blank means not extracted as independent variables
  2. Gc circ glucocorticoid administration for circulatory collapse, SD SD score of birth weight, Gc CLD glucocorticoid administration for CLD, AS antenatal glucocorticoid administration, Bf amount of human milk
  3. ※p < 0.001
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Clinical Epigenetics

ISSN: 1868-7083

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