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Table 2 The relationships between methylation status at 2 months and pre- and postnatal environments

From: Postnatal relative adrenal insufficiency results in methylation of the glucocorticoid receptor gene in preterm infants: a retrospective cohort study

CpG no. 2 3 4 5 8 9 10 11
Gc circ 0.568 0.877 0.968 0.754 0.715 0.855 0.66  
SD − 0.547       − 0.352  
Gc CLD − 0.365     0.327    
AS − 0.193     − 0.298 − 0.254   
Bf         − 0.492
Adjusted R2 0.922 0.774 0.933 0.544 0.752 0.858 0.724 0.198
Overall p 0.032
CpG no. 12 15 16 17 18 19 23 24
Gc circ 0.802 0.789 0.837 0.755 0.887 0.842 0.894 0.639
SD   − 0.255 − 0.234 − 0.285     − 0.364
Gc CLD         
Bf         
Adjusted R2 0.623 0.838 0.909 0.811 0.89 0.691 0.788 0.702
Overall p
CpG no. 25 26 31 32 33 34 36 39
Gc circ 0.81 0.865 0.908 0.877 0.892 0.902   0.827
SD − 0.246        
Gc CLD         
AS         
Bf        − 0.506  
Adjusted R2 0.869 0.734 0.814 0.756 0.784 0.803 0.213 0.665
Overall p 0.027
  1. Regression coefficients of independent variables are shown. A blank means not extracted as independent variables
  2. Gc circ glucocorticoid administration for circulatory collapse, SD SD score of birth weight, Gc CLD glucocorticoid administration for CLD, AS antenatal glucocorticoid administration, Bf amount of human milk
  3. p < 0.001