Table 3 Diagnostic performance of the three-gene methylation classifier in the training and testing set of samples (at fixed sensitivity of 85% in the training set)
From: Urine cell-based DNA methylation classifier for monitoring bladder cancer
Training set | Testing set | |
|---|---|---|
Overall | ||
N samples | 111 BC/57 C | 173 R-PFBC/285 NR-PFBC |
AUC | 0.874 | 0.741 |
SN (%) | 84.68 | 89.6 |
SP (%) | 68.42 | 30.53 |
PPV (%) | 83.93 | 43.91 |
NPV (%) | 69.64 | 82.86 |
Non-high-risk NMIBC | ||
N samples | 26 BC/57 C | 61 R-PFBC/285 NR-PFBC |
SN (%) | 73.08 | 88.52 |
SP (%) | 68.42 | 30.53 |
PPV (%) | 51.35 | 21.43 |
NPV (%) | 84.78 | 92.55 |
High-risk NMIBC | ||
N samples | 60 BC/57 C | 112 R-PFBC/285 NR-PFBC |
SN (%) | 86.67 | 90.18 |
SP (%) | 68.42 | 30.53 |
PPV (%) | 74.29 | 33.78 |
NPV (%) | 82.98 | 88.78 |
MIBC | ||
N samples | 25 BC/57C | – |
SN (%) | 92 | – |
SP (%) | 68.42 | – |
PPV (%) | 56.1 | – |
NPV (%) | 95.12 | – |
Low-grade | ||
N samples | 47 BC/57 C | 96 R-PFBC/285 NR-PFBC |
SN (%) | 76.6 | 90.62 |
SP (%) | 68.42 | 30.53 |
PPV (%) | 66.67 | 30.53 |
NPV (%) | 78 | 90.62 |
High grade | ||
N samples | 64 BC/57 C | 77 R-PFBC/285 NR-PFBC |
SN (%) | 90.62 | 88.31 |
SP (%) | 68.42 | 30.53 |
PPV (%) | 76.32 | 25.56 |
NPV (%) | 86.67 | 90.62 |