Fig. 7
From: miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway
Proposed mechanistic scheme: miR-29c suppresses breast cancer by the TIMP3/STAT1/FOXO1 pathway. The expression of miR-29c was decreased in breast cancer, which leading to the elevated expression of DNMT3B that is critical for promoter methylation and decreases the expression of TIMP3. As a result, the expression of STAT1 was increased, and it inhibits the expression of FOXO1, leading to proliferation, migration, and invasion of breast cancer cells