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Table 5 Performance of predictive CpG sets reported by Almstrup et al. in this study

From: Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes

 

Among COAST females (N = 30)

Among COAST males (N = 25)

Among COAST males and females combined (N = 55)

Specificity

Sensitivity

Specificity

Sensitivity

Specificity

Sensitivity

94 puberty classifiers (N = 75)

83.3%

96.7%

92.0%

92.0%

92.7%

87.3%

133 reproductive hormonea classifiers (N = 104)

86.7%

86.2%

72.0%

96.0%

90.9%

90.9%

  1. aFollicle stimulating hormone (FSH), luteinizing hormone (LH), anti-Mullerian hormone (AMH), testosterone (T), estradiol (E2), inhibin B
  2. Numbers in parentheses in first column refer to the number of CpGs in each subset reported by Almstrup that are present in this study