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Table 3 Enrichment categories of four significant protein-protein interaction networks in females constructed using Ingenuity Pathway Analysis (networks shown in Additional file 7)

From: Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes

Network (IPA Score)

Enrichr results

Enrichment category

Database

Adj. P value

1 (47)

Phosphatidylinositol signaling TGF-β receptor signaling

KEGG 2016

Panther 2016

0.0064

0.043

2 (41)

FGF signaling pathway

Panther 2016

0.0073

3 (33)

Insulin-like growth factor-1 (IGF-1) signaling

NCI-Nature 2016

0.0098

4 (32)

Validated estrogen receptor alpha network

NCI-Nature 2016

0.0018

  1. Adjusted P values were determined by performing the Fisher Exact Test for many random gene sets in order to compute a mean rank and SD from the expected rank for each term in the gene-set library