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Table 3 Enrichment categories of four significant protein-protein interaction networks in females constructed using Ingenuity Pathway Analysis (networks shown in Additional file 7)

From: Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes

Network (IPA Score) Enrichr results
Enrichment category Database Adj. P value
1 (47) Phosphatidylinositol signaling TGF-β receptor signaling KEGG 2016 Panther 2016 0.0064 0.043
2 (41) FGF signaling pathway Panther 2016 0.0073
3 (33) Insulin-like growth factor-1 (IGF-1) signaling NCI-Nature 2016 0.0098
4 (32) Validated estrogen receptor alpha network NCI-Nature 2016 0.0018
  1. Adjusted P values were determined by performing the Fisher Exact Test for many random gene sets in order to compute a mean rank and SD from the expected rank for each term in the gene-set library