Fig. 1

Volcano plot showing differences in methylation between 8 and 14 years of age in males and females combined (DMPs in 55 paired samples). Significant (FDR = 5%) DMPs are shown as non-black circles. Female puberty-associated DMPs (347 in 30 paired female samples) are shown in red, male puberty-associated DMPs (50 DMPs in 25 paired samples) are shown in blue, and CpGs identified as being differentially methylated in the combined sample (48 in 55 paired samples) are shown in gray. The x axis shows –log10 P values and the y axis plots the mean difference in methylation β values. The horizontal line denotes significant CpGs at an FDR of 10%