Table 4 Genes hypermethylated in promoters with significantly decreased gene expression
Gene symbol | DNA methylation | Gene expression | Correlation analysis | |||||
|---|---|---|---|---|---|---|---|---|
Probe ID | DNAm β diff. (%) | Adjusted P value (< 0.25) | Probe ID | FC | P value (< 0.05) | Spearman’s rank correlation coefficient | P value (< 0.05) | |
UCN | cg20442078 | 5.6 | 0.17 | 8051061 | − 1.12 | 3.61E−02 | − 8.42E−01 | 2.23E−03 |
CCHCR1 | cg00160818 | 1.9 | 0.17 | 8124868 | − 1.14 | 1.73E−02 | − 7.45E−01 | 9.21E−03 |
CRB3 | cg14782015 | 4.3 | 0.20 | 8025041 | − 1.13 | 1.84E−02 | − 7.21E−01 | 1.21E−02 |
AGBL4 | cg21834207 | 3.2 | 0.13 | 7915971 | − 1.17 | 1.29E−02 | − 6.73E−01 | 1.97E−02 |
INSL3 | cg10174482 | 4.2 | 0.13 | 8035345 | − 1.13 | 4.94E−02 | − 6.36E−01 | 2.72E−02 |
ANKRD30B | cg21293934 | 11.2 | 0.21 | 8069499 | − 1.17 | 2.24E−02 | − 6.08E−01 | 3.11E−02 |
FADS1 | cg16213375 | 3.6 | 0.16 | 7948612 | − 1.8 | 9.55E−04 | − 5.88E−01 | 4.01E−02 |
PAPL | cg18481683 | 2.3 | 0.24 | 8028570 | − 1.19 | 1.45E−02 | − 5.52E−01 | 5.21E−02 |
MOGAT1 | cg12678667 | 4 | 0.15 | 8048725 | − 1.28 | 3.87E−02 | − 4.67E−01 | 8.91E−02 |
PPP1R1B | cg09762778 | 5 | 0.12 | 8006865 | − 1.27 | 4.74E−02 | − 4.67E−01 | 8.91E−02 |
PRUNE2 | cg00390775 | 4.4 | 0.15 | 8161884 | − 1.31 | 1.91E−02 | − 3.82E−01 | 1.39E−01 |
CIDEA | cg18309817 | 1.8 | 0.18 | 8020211 | − 1.32 | 3.21E−02 | − 2.97E−01 | 2.03E−01 |
PCYT2 | cg19583655 | 6.2 | 0.21 | 8019280 | − 1.26 | 6.38E−04 | − 1.88E−01 | 3.04E−01 |
SCUBE1 | cg07697597 | 1.7 | 0.23 | 8076586 | − 1.23 | 9.03E−03 | − 4.24E−02 | 4.59E−01 |