Table 2 Differentially methylated CpG sites in PPAT between obese/overweight PCa patients and normal weight controls
Probe ID | Chromosome and coordinate (GRCh37) | Nearest gene | Relation to gene region | Relation to CpG island | DNAm β difference (%) | P value | Adjusted P value (< 0.25) |
|---|---|---|---|---|---|---|---|
Hypermethylated CpG sites | |||||||
cg09476130 | chr1:159870086 | CCDC19 | TSS200 | Island | 12.1 | 1.87E−03 | 0.213 |
cg21293934 | chr18:14748230 | ANKRD30B | TSS200 | Island | 11.2 | 1.83E−03 | 0.212 |
cg16925210 | chr2:216946718 | PECR | TSS200 | Island | 11.2 | 2.44E−03 | 0.226 |
cg11625005 | chr5:1295737 | TERT | TSS1500 | Island | 11.1 | 1.38E−03 | 0.196 |
cg07039560 | chr5:140683681 | SLC25A2 | TSS200 | Island | 10.5 | 2.24E−03 | 0.222 |
cg00329447 | chr8:145028170 | PLEC1 | TSS200 | Island | 10.1 | 3.41E−03 | 0.244 |
cg24463471 | chr1:25257978 | RUNX3 | TSS1500 | Island | 9.9 | 3.58E−04 | 0.155 |
cg26149485 | chr19:2428350 | TIMM13 | TSS1500 | Island | 9.7 | 3.36E−04 | 0.154 |
cg05156901 | chr22:51016646 | CPT1B | TSS200 | Island | 9.3 | 3.05E−03 | 0.238 |
cg18689454 | chr21:45705694 | AIRE | TSS200 | Island | 9.3 | 7.33E−04 | 0.174 |
cg01454592 | chr3:49236800 | CCDC36 | TSS200 | Island | 9.3 | 2.89E−03 | 0.236 |
cg24041556 | chr19:10736059 | SLC44A2 | TSS200 | Island | 9.1 | 2.15E−05 | 0.110 |
cg22257574 | chr9:135754383 | C9orf98 | TSS200 | Island | 9.0 | 1.97E−05 | 0.110 |
cg23005885 | chr15:90543450 | ZNF710 | TSS1500 | Island | 8.9 | 6.20E−04 | 0.169 |
cg05726756 | chr17:46608288 | HOXB1 | TSS200 | Island | 8.6 | 1.67E−03 | 0.206 |
cg12782180 | chr7:127880932 | LEP | TSS1500 | Island | 8.5 | 9.78E−04 | 0.184 |
cg04675542 | chr5:150284416 | ZNF300 | TSS200 | Island | 8.4 | 3.42E−03 | 0.244 |
cg10134527 | chr6:33283015 | TAPBP | TSS1500 | Island | 8.4 | 3.19E−03 | 0.241 |
cg23387569 | chr12:58120011 | LOC100130776 | TSS200 | Island | 8.4 | 3.39E−04 | 0.155 |
cg17205324 | chr14:23835595 | EFS | TSS1500 | Island | 8.3 | 1.46E−04 | 0.133 |
cg24402300 | chr19:55591437 | EPS8L1 | TSS1500 | Island | 8.2 | 2.02E−03 | 0.216 |
cg18081258 | chr14:21494161 | NDRG2 | TSS1500 | Island | 8.2 | 1.05E−03 | 0.187 |
cg00730561 | chr10:102279703 | SEC31B | TSS200 | Island | 8.1 | 4.82E−04 | 0.162 |
cg17791651 | chr1:38513489 | POU3F1 | TSS1500 | Island | 8.0 | 1.31E−04 | 0.133 |
Hypomethylated CpG sites | |||||||
cg03462171 | chr16:1664488 | CRAMP1L | TSS200 | Island | − 8.2 | 2.30E−03 | 0.223 |
cg11648730 | chr5:92907151 | FLJ42709 | TSS1500 | Island | − 6.4 | 1.72E−03 | 0.207 |
cg04558166 | chr1:210001279 | C1orf107 | TSS200 | Island | − 4.0 | 1.75E−03 | 0.209 |
cg25472897 | chr8:145560555 | SCRT1 | TSS1500 | Island | − 3.1 | 1.53E−03 | 0.201 |
cg17612948 | chr5:110427863 | WDR36 | TSS200 | Island | − 3.0 | 1.70E−03 | 0.207 |
cg21665057 | chr3:196295764 | WDR53 | TSS1500 | Island | − 2.4 | 2.42E−03 | 0.225 |
cg12683173 | chr7:69063404 | AUTS2 | TSS1500 | Island | − 1.4 | 3.30E−03 | 0.242 |
cg04872557 | chr1:76190008 | ACADM | TSS200 | Island | − 1.0 | 1.96E−03 | 0.215 |