Fig. 2

Protein-protein interaction analysis. a A subnetwork composing of 247 nodes and 403 edges was generated using methylated genes. Blue dots represent the genes involved in prostate cancer; red and pink dots represent the seeds (methylated genes) according to the different P values; the gray dots represent the proteins which were closely interacted with the seeds, and the circle size represents the node degree. b The pathway enrichment analysis shows the subnetwork is mainly enriched in cancer pathways (P < 0.0001)