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Table 4 Life course analysis— contribution of fetal and postnatal influences (FDR threshold < 0.05)—asthma pathway. For the prenatal analysis, results are expressed as the change in log(IgE) concentration per 1% increase in cord blood methylation value. While for the postnatal analysis, results are expressed as the change in log(IgE) concentration per 1% increase in Δ-DNAm methylation value

From: Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach

     Prenatal influences Postnatal influences
CpG CHR MAPINFO Gene Estimate P value FDR Estimate P value FDR
Life course analysis—postnatal influences (asthma pathway)
 cg26787239 5 132,008,525 IL4 − 0.12 9.00E−02 6.91E−01 − 0.18 1.94E−05 0.020
 cg01310029 3 3,152,374 IL5RA − 0.09 7.48E−02 6.73E−01 − 0.18 3.55E−06 0.005
 cg02970679 17 56,269,818 EPX − 0.17 9.50E−04 2.86E−01 − 0.25 5.06E−23 7.95E−18
 cg25173129 17 56,269,410 EPX − 0.16 5.73E−03 4.22E−01 − 0.22 2.59E−08 9.80E−05
 cg27469152 17 56,282,313 EPX − 0.10 5.02E−02 6.32E−01 − 0.19 2.59E−07 6.53E−04
 cg18421167 17 56,276,490 EPX − 0.09 2.38E−01 8.07E−01 − 0.25 1.83E−06 0.003
 cg08105265 17 56,274,480 EPX − 0.04 6.46E−01 9.40E−01 − 0.22 1.55E−05 0.017
 cg12819873 11 57,157,632 PRG2 − 0.12 8.55E−03 4.60E−01 − 0.23 1.21E−09 9.05E-06
 cg15700636 11 57,156,050 PRG2 − 0.08 3.19E−02 5.85E−01 − 0.18 4.13E−08 1.46E−04
 cg08295410 5 156,990,663 ADAM19 − 0.31 4.79E−03 4.09E−01 − 0.40 2.70E−05 0.026
  1. Model adjusted for maternal [age at enrollment (continuous), smoking status (smoking during pregnancy/former/never), college graduate (yes/no), maternal atopy history (yes/no)], children [child’s sex (female/male), race (white/black/other), gestational age (continuous), age at blood drawn (continuous)], and the cell-type proxys using the first five ReFACTor components estimated from cord blood
  2. Corresponding model: log(IgE) = β0 + β1CpG_cbi + β2ΔCpGi + β3X3 + … + βpXp + η
  3. Life course analysis—prenatal influence: association between cord blood methylation and mid-childhood IgE independent of postnatal changes in DNA methylation, which correspond to β1CpG_cbi;
  4. Life course analysis—postnatal influence: association between changes in postnatal DNA methylation from birth and mid-childhood IgE independent of baseline/cord blood DNA methylation, which correspond to ΔCpGi