From: Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach
 |  |  |  | Prenatal influences | Postnatal influences (Δ-DNAm) | ||||
---|---|---|---|---|---|---|---|---|---|
CpG | CHR | MAPINFO | Gene | Estimate | P value | FDR | Estimate | P value | FDR |
Life course analysis—prenatal influences | |||||||||
 cg25854298 | 10 | 73,936,754 | ASCC1 | − 0.36 | 8.02E−09 | 0.003 | − 0.40 | 1.80E−13 | 6.28E−09 |
 cg16416603 | 20 | 57,593,014 | TUBB1 | 0.58 | 5.17E−08 | 0.008 | 0.28 | 1.32E−04 | 8.24E−02 |
 cg11848324 | 14 | 20,403,845 | OR4K1 | 0.57 | 1.48E−07 | 0.016 | 0.44 | 3.35E−06 | 5.26E−03 |
 cg19549714 | 18 | 3,447,713 | TGIF1 | − 2.00 | 2.40E−07 | 0.017 | − 0.10 | 4.45E−01 | 9.71E−01 |
 cg23933289 | 1 | 178,998,656 | FAM20B | − 0.18 | 2.66E−07 | 0.017 | − 0.17 | 8.01E-08 | 2.54E−04 |
 cg24576940 | 7 | 150,648,283 | KCNH2 | − 1.54 | 3.31E−07 | 0.017 | − 1.66 | 2.95E−08 | 1.10E−04 |
 cg13443997 | 9 | 139,743,586 | PHPT1 | − 3.39 | 7.11E−07 | 0.028 | − 1.83 | 1.50E−03 | 3.32E−01 |
 cg19954205 | 12 | 122,211,282 | TMEM120B | − 1.20 | 7.20E−07 | 0.028 | − 0.55 | 1.72E−02 | 7.37E−01 |
 cg01782059 | 1 | 44,715,942 | ERI3 | − 0.96 | 1.25E−06 | 0.033 | − 0.60 | 4.04E−04 | 1.69E−01 |
 cg02133716 | 8 | 128,981,622 | PVT1 | − 0.45 | 1.25E−06 | 0.033 | − 0.54 | 2.63E−11 | 3.31E−07 |
 cg06226630 | 4 | 48,493,420 | ZAR1 | − 0.39 | 1.24E−06 | 0.033 | − 0.02 | 5.24E−01 | 9.76E−01 |
 cg20675173 | 3 | 43,795,541 | – | − 1.22 | 1.03E−06 | 0.033 | − 0.72 | 1.11E−03 | 2.91E−01 |
 cg08067346 | 16 | 25,011,481 | ARHGAP17 | − 0.24 | 1.44E−06 | 0.035 | − 0.30 | 2.18E−11 | 2.85E−07 |
 cg09597192 | 6 | 32,141,591 | AGPAT1 | − 0.31 | 1.78E−06 | 0.040 | − 0.28 | 3.70E−06 | 5.67E−03 |
 cg16096766 | 13 | 52,419,714 | FLJ37307 | − 0.36 | 2.30E−06 | 0.048 | − 0.19 | 2.48E−04 | 1.23E−01 |
 cg00026222 | 1 | 2,144,244 | – | − 1.02 | 2.63E−06 | 0.049 | − 0.29 | 9.59E−02 | 9.09E−01 |
 cg24575275 | 7 | 1,094,737 | C7orf50 | − 0.31 | 2.49E−06 | 0.049 | − 0.02 | 5.23E−01 | 9.76E−01 |
Life course analysis—postnatal influences (top 20 methylation sites) | |||||||||
 cg11699125 | 1 | 6,341,327 | ACOT7 | − 0.10 | 3.29E−02 | 5.88E-01 | − 0.25 | 2.81E−23 | 7.95E−18 |
 cg02970679 | 17 | 56,269,818 | EPX | − 0.17 | 9.50E−04 | 2.86E-01 | − 0.25 | 5.06E−23 | 7.95E−18 |
 cg24491618 | 7 | 150,649,807 | KCNH2 | − 0.12 | 1.23E−03 | 3.05E-01 | − 0.19 | 2.12E−16 | 2.22E−11 |
 cg01614759 | 10 | 45,495,435 | C10orf25 | − 0.17 | 2.17E−03 | 3.46E-01 | − 0.28 | 2.97E−16 | 2.33E−11 |
 cg13054523 | 17 | 81,055,722 | – | − 0.30 | 9.45E−05 | 1.53E-01 | −0.43 | 4.23E−15 | 2.66E−10 |
 cg21220721 | 1 | 6,341,230 | ACOT7 | 0.01 | 7.03E−01 | 9.51E-01 | − 0.11 | 1.30E−14 | 6.81E−10 |
 cg10065736 | 12 | 117,440,120 | FBXW8 | − 0.10 | 2.28E−02 | 5.53E-01 | − 0.18 | 2.73E−14 | 1.23E−09 |
 cg06558622 | 7 | 149,543,177 | ZNF862 | − 0.29 | 3.37E−05 | 1.02E-01 | − 0.41 | 8.05E−14 | 3.16E−09 |
 cg25854298 | 10 | 73,936,754 | ASCC1 | − 0.36 | 8.02E−09 | 2.52E-03 | − 0.40 | 1.80E−13 | 6.28E−09 |
 cg05300717 | 11 | 65,546,210 | DKFZp761E198 | 0.0002 | 9.93E−01 | 9.99E-01 | − 0.33 | 2.11E−13 | 6.63E−09 |
 cg09596645 | 3 | 181,897,670 | – | − 0.15 | 2.74E−03 | 3.67E-01 | − 0.25 | 5.56E−13 | 1.59E−08 |
 cg19928703 | 13 | 30,143,971 | SLC7A1 | − 0.19 | 3.05E−03 | 3.75E-01 | − 0.31 | 1.06E−12 | 2.78E−08 |
 cg18368116 | 14 | 21,436,271 | – | − 0.13 | 2.02E−02 | 5.40E-01 | − 0.27 | 1.91E−12 | 4.62E−08 |
 cg20885063 | 17 | 17,939,419 | ATPAF2 | − 0.16 | 1.85E−04 | 1.90E-01 | − 0.23 | 4.05E−12 | 9.09E−08 |
 cg08077807 | 14 | 62,001,072 | PRKCH | − 0.53 | 7.33E−04 | 2.63E-01 | − 0.76 | 4.45E−12 | 9.11E−08 |
 cg07908654 | 13 | 41,631,052 | – | − 0.20 | 3.94E−06 | 5.14E-02 | − 0.26 | 4.64E−12 | 9.11E−08 |
 cg08940169 | 16 | 88,540,241 | ZFPM1 | − 0.05 | 1.56E−01 | 7.57E-01 | − 0.18 | 6.34E−12 | 1.17E−07 |
 cg18879389 | 21 | 43,771,120 | TFF2 | − 0.16 | 6.64E−04 | 2.58E-01 | − 0.28 | 6.73E−12 | 1.17E−07 |
 cg20263733 | 3 | 130,616,293 | ATP2C1 | − 0.25 | 4.25E−03 | 3.99E-01 | − 0.50 | 7.45E−12 | 1.23E−07 |
 cg02985445 | 7 | 97,908,505 | – | − 0.08 | 3.50E−02 | 5.94E-01 | − 0.18 | 8.09E−12 | 1.27E−07 |
Life course analysis—prenatal and postnatal influences | |||||||||
 cg25854298 | 10 | 73,936,754 | ASCC1 | − 0.36 | 8.02E−09 | 0.003 | − 0.40 | 1.80E−13 | 6.28E−09 |
 cg11848324 | 14 | 20,403,845 | OR4K1 | 0.57 | 1.48E−07 | 0.016 | 0.44 | 3.35E−06 | 0.005 |
 cg23933289 | 1 | 178,998,656 | FAM20B | − 0.18 | 2.66E−07 | 0.017 | − 0.17 | 8.01E−08 | 2.54E−04 |
 cg24576940 | 7 | 150,648,283 | KCNH2 | − 1.54 | 3.31E−07 | 0.017 | − 1.66 | 2.95E−08 | 1.10 E−04 |
 cg02133716 | 8 | 128,981,622 | PVT1 | − 0.45 | 1.25E−06 | 0.033 | − 0.54 | 2.63E−11 | 3.31E−07 |
 cg08067346 | 16 | 25,011,481 | ARHGAP17 | − 0.24 | 1.44E−06 | 0.035 | − 0.30 | 2.18E−11 | 2.85E−07 |
 cg09597192 | 6 | 32,141,591 | AGPAT1 | − 0.31 | 1.78E−06 | 0.040 | − 0.28 | 3.70E−06 | 0.006 |