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Table 2 Association between cord blood DNA methylation and mid-childhood IgE (FDR threshold < 0.05). Results are expressed as the change in log(IgE) concentration per 1% increase in cord blood methylation value

From: Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach

CpG CHR MAPINFO Gene Estimate P value FDR
cg06226630 4 48,493,420 ZAR1 − 0.40 1.15E−07 0.013
cg03307893 15 26,108,683 ATP10A − 0.76 1.20E−07 0.013
cg13322072 7 98,784,083 KPNA7 − 0.11 1.23E−07 0.013
cg16797808 14 99,948,289 SETD3;CCNK − 0.90 3.18E−07 0.023
cg09535168 19 19,431,582 MAU2 − 1.44 3.91E−07 0.023
cg04122974 22 39,916,495 ATF4 − 3.02 4.46E−07 0.023
cg01527777 11 71,956,145 PHOX2A − 0.24 6.06E−07 0.027
cg24575275 7 1,094,737 C7orf50 − 0.29 9.23E−07 0.032
cg14920426 5 176,924,420 PDLIM7 − 1.00 1.01E−06 0.032
cg05399209 19 46,010,836 VASP − 1.33 1.03E−06 0.032
cg09507928 5 140,027,484 IK;NDUFA2 − 2.03 1.46E−06 0.040
cg24114890 14 23,834,349 EFS − 0.76 1.65E−06 0.040
cg05063806 1 36,772,417 C1orf113 − 1.26 1.79E−06 0.040
cg14167858 1 120,199,593 0.10 1.83E−06 0.040
cg02228675 17 40,259,724 DHX58 − 0.27 1.90E−06 0.040
cg14607755 9 139,962,279 C9orf140 − 0.49 2.25E−06 0.044
cg24630419 1 217,311,608 ESRRG − 0.41 2.49E−06 0.046
cg27212903 15 92,708,880 SLCO3A1 0.97 2.91E−06 0.048
cg14605590 9 94,900,583 LOC100128076 − 0.16 2.93E−06 0.048
  1. Model adjusted for maternal [age at enrollment (continuous), smoking status (smoking during pregnancy/former/never), college graduate (yes/no), maternal atopy history (yes/no)], children [child’s sex (female/male), race/ethnicity (white/black/other), gestational age (continuous), age at blood drawn (continuous)], and the cell-type proxys using the first five ReFACTor components estimated from cord blood
  2. Corresponding model: log(IgE) = α0 + α1CpG_cbi + α2X2 + … + αpXp + ε