Fig. 1
From: Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach
Conceptural model of the lifecourse framework. Path (a): epigenetic modifications established at birth may be associated with IgE levels in childhood independent of factors operating postnatally; path (b): epigenetic marks established at birth may be further influenced by postnatal experiences and exposures; and path (c): postnatal experiences and exposures may be associated with IgE levels independent of prenatal factors