TY - JOUR AU - Ferlay, J. AU - Soerjomataram, I. AU - Dikshit, R. AU - Eser, S. AU - Mathers, C. AU - Rebelo, M. PY - 2015 DA - 2015// TI - Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 JO - Int J Cancer VL - 136 UR - https://doi.org/10.1002/ijc.29210 DO - 10.1002/ijc.29210 ID - Ferlay2015 ER - TY - JOUR AU - Arnold, M. AU - Sierra, M. S. AU - Laversanne, M. AU - Soerjomataram, I. AU - Jemal, A. AU - Bray, F. PY - 2017 DA - 2017// TI - Global patterns and trends in colorectal cancer incidence and mortality JO - Gut VL - 66 UR - https://doi.org/10.1136/gutjnl-2015-310912 DO - 10.1136/gutjnl-2015-310912 ID - Arnold2017 ER - TY - JOUR AU - Ng, S. C. AU - Lau, J. Y. W. AU - Chan, F. K. L. AU - Suen, B. Y. AU - Leung, W. K. AU - Tse, Y. K. PY - 2013 DA - 2013// TI - Increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer JO - Gastroenterology VL - 144 UR - https://doi.org/10.1053/j.gastro.2012.11.011 DO - 10.1053/j.gastro.2012.11.011 ID - Ng2013 ER - TY - JOUR AU - Brenner, H. AU - Stock, C. AU - Hoffmeister, M. PY - 2015 DA - 2015// TI - Colorectal cancer screening: the time to act is now JO - BMC Med VL - 13 UR - https://doi.org/10.1186/s12916-015-0498-x DO - 10.1186/s12916-015-0498-x ID - Brenner2015 ER - TY - JOUR AU - Salas Trejo, D. AU - Portillo Villares, I. AU - Espinàs Piñol, J. A. AU - Ibáñez Cabanell, J. AU - Vanaclocha Espí, M. AU - Pérez Riquelme, F. PY - 2017 DA - 2017// TI - Implementation of colorectal cancer screening in Spain JO - Eur J Cancer Prev VL - 26 UR - https://doi.org/10.1097/CEJ.0000000000000232 DO - 10.1097/CEJ.0000000000000232 ID - Salas Trejo2017 ER - TY - JOUR AU - Castro, I. AU - Cubiella, J. AU - Rivera, C. AU - González-Mao, C. AU - Vega, P. AU - Soto, S. PY - 2014 DA - 2014// TI - Fecal immunochemical test accuracy in familial risk colorectal cancer screening JO - Int J Cancer VL - 134 UR - https://doi.org/10.1002/ijc.28353 DO - 10.1002/ijc.28353 ID - Castro2014 ER - TY - JOUR AU - Kim, N. H. AU - Yang, H. -. J. AU - Park, S. -. K. AU - Park, J. H. AU - Park, D. I. AU - Sohn, C. I. PY - 2016 DA - 2016// TI - Does low threshold value use improve proximal neoplasia detection by fecal immunochemical test? JO - Dig Dis Sci VL - 61 UR - https://doi.org/10.1007/s10620-016-4169-3 DO - 10.1007/s10620-016-4169-3 ID - Kim2016 ER - TY - JOUR AU - Shah, R. AU - Jones, E. AU - Vidart, V. AU - Kuppen, P. J. K. AU - Conti, J. A. AU - Francis, N. K. PY - 2014 DA - 2014// TI - Biomarkers for early detection of colorectal cancer and polyps: systematic review JO - Cancer Epidemiol Biomark Prev VL - 23 UR - https://doi.org/10.1158/1055-9965.EPI-14-0412 DO - 10.1158/1055-9965.EPI-14-0412 ID - Shah2014 ER - TY - JOUR AU - Song, L. AU - Li, Y. PY - 2017 DA - 2017// TI - Progress on the clinical application of the SEPT9 gene methylation assay in the past 5 years JO - Biomark Med VL - 11 UR - https://doi.org/10.2217/bmm-2017-0091 DO - 10.2217/bmm-2017-0091 ID - Song2017 ER - TY - JOUR AU - Lao, V. V. AU - Grady, W. M. PY - 2012 DA - 2012// TI - Epigenetics and colorectal cancer JO - Nat Rev Gastroenterol Hepatol VL - 8 UR - https://doi.org/10.1038/nrgastro.2011.173 DO - 10.1038/nrgastro.2011.173 ID - Lao2012 ER - TY - JOUR AU - Bariol, C. AU - Suter, C. AU - Cheong, K. AU - Ku, S. L. AU - Meagher, A. AU - Hawkins, N. PY - 2003 DA - 2003// TI - The relationship between hypomethylation and CpG island methylation in colorectal neoplasia JO - Am J Pathol VL - 162 UR - https://doi.org/10.1016/S0002-9440(10)63932-6 DO - 10.1016/S0002-9440(10)63932-6 ID - Bariol2003 ER - TY - JOUR AU - Øster, B. AU - Thorsen, K. AU - Lamy, P. AU - Wojdacz, T. K. AU - Hansen, L. L. AU - Birkenkamp-Demtröder, K. PY - 2011 DA - 2011// TI - Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas JO - Int J Cancer VL - 129 UR - https://doi.org/10.1002/ijc.25951 DO - 10.1002/ijc.25951 ID - Øster2011 ER - TY - JOUR AU - Beggs, A. D. AU - Jones, A. AU - El-Bahwary, M. AU - Abulafi, M. AU - Hodgson, S. V. AU - Tomlinson, I. P. M. PY - 2013 DA - 2013// TI - Whole-genome methylation analysis of benign and malignant colorectal tumours JO - J Pathol VL - 229 UR - https://doi.org/10.1002/path.4132 DO - 10.1002/path.4132 ID - Beggs2013 ER - TY - JOUR AU - Luo, Y. AU - Wong, C. J. AU - Kaz, A. M. AU - Dzieciatkowski, S. AU - Carter, K. T. AU - Morris, S. M. PY - 2014 DA - 2014// TI - Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer JO - Gastroenterology VL - 147 UR - https://doi.org/10.1053/j.gastro.2014.04.039 DO - 10.1053/j.gastro.2014.04.039 ID - Luo2014 ER - TY - JOUR AU - Laird, P. W. PY - 2010 DA - 2010// TI - Principles and challenges of genome-wide DNA methylation analysis JO - Nat Rev Genet VL - 11 UR - https://doi.org/10.1038/nrg2732 DO - 10.1038/nrg2732 ID - Laird2010 ER - TY - JOUR AU - Fan, S. AU - Chi, W. PY - 2016 DA - 2016// TI - Methods for genome-wide DNA methylation analysis in human cancer JO - Brief Funct Genomics VL - 15 UR - https://doi.org/10.1093/bfgp/elw010 DO - 10.1093/bfgp/elw010 ID - Fan2016 ER - TY - JOUR AU - Norton, N. AU - Williams, N. M. AU - O’Donovan, M. C. AU - Owen, M. J. PY - 2004 DA - 2004// TI - DNA pooling as a tool for large-scale association studies in complex traits JO - Ann Med VL - 36 UR - https://doi.org/10.1080/07853890310021724 DO - 10.1080/07853890310021724 ID - Norton2004 ER - TY - JOUR AU - Pearson, J. V. AU - Huentelman, M. J. AU - Halperin, R. F. AU - Tembe, W. D. AU - Melquist, S. AU - Homer, N. PY - 2007 DA - 2007// TI - Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide–polymorphism association studies JO - Am J Hum Genet VL - 80 UR - https://doi.org/10.1086/510686 DO - 10.1086/510686 ID - Pearson2007 ER - TY - JOUR AU - Gallego-Fabrega, C. AU - Carrera, C. AU - Muiño, E. AU - Montaner, J. AU - Krupinski, J. AU - Fernandez-Cadenas, I. PY - 2015 DA - 2015// TI - DNA methylation levels are highly correlated between pooled samples and averaged values when analysed using the Infinium HumanMethylation450 BeadChip array JO - Clin Epigenetics VL - 7 UR - https://doi.org/10.1186/s13148-015-0097-x DO - 10.1186/s13148-015-0097-x ID - Gallego-Fabrega2015 ER - TY - JOUR AU - Schwarzenbach, H. AU - Hoon, D. S. B. AU - Pantel, K. PY - 2011 DA - 2011// TI - Cell-free nucleic acids as biomarkers in cancer patients JO - Nat Rev Cancer VL - 11 UR - https://doi.org/10.1038/nrc3066 DO - 10.1038/nrc3066 ID - Schwarzenbach2011 ER - TY - JOUR AU - Krishnamurthy, N. AU - Spencer, E. AU - Torkamani, A. AU - Nicholson, L. PY - 2017 DA - 2017// TI - Liquid biopsies for cancer: coming to a patient near you JO - J Clin Med VL - 6 UR - https://doi.org/10.3390/jcm6010003 DO - 10.3390/jcm6010003 ID - Krishnamurthy2017 ER - TY - JOUR AU - Zhai, R. AU - Zhao, Y. AU - Su, L. AU - Cassidy, L. AU - Liu, G. AU - Christiani, D. C. PY - 2012 DA - 2012// TI - Genome-wide DNA methylation profiling of cell-free serum DNA in esophageal adenocarcinoma and Barrett esophagus JO - Neoplasia VL - 14 UR - https://doi.org/10.1593/neo.111626 DO - 10.1593/neo.111626 ID - Zhai2012 ER - TY - JOUR AU - Bosch, L. J. W. AU - Mongera, S. AU - sive Droste, J. S. T. AU - Oort, F. A. AU - van Turenhout, S. T. AU - Penning, M. T. PY - 2012 DA - 2012// TI - Analytical sensitivity and stability of DNA methylation testing in stool samples for colorectal cancer detection JO - Cell Oncol VL - 35 UR - https://doi.org/10.1007/s13402-012-0092-6 DO - 10.1007/s13402-012-0092-6 ID - Bosch2012 ER - TY - JOUR AU - Forat, S. AU - Huettel, B. AU - Reinhardt, R. AU - Fimmers, R. AU - Haidl, G. AU - Denschlag, D. PY - 2016 DA - 2016// TI - Methylation markers for the identification of body fluids and tissues from forensic trace evidence JO - PLoS One VL - 11 UR - https://doi.org/10.1371/journal.pone.0147973 DO - 10.1371/journal.pone.0147973 ID - Forat2016 ER - TY - JOUR AU - Galanopoulos, M. AU - Tsoukalas, N. AU - Papanikolaou, I. S. AU - Tolia, M. AU - Gazouli, M. AU - Mantzaris, G. J. PY - 2017 DA - 2017// TI - Abnormal DNA methylation as a cell-free circulating DNA biomarker for colorectal cancer detection: a review of literature JO - World J Gastrointest Oncol VL - 9 UR - https://doi.org/10.4251/wjgo.v9.i4.142 DO - 10.4251/wjgo.v9.i4.142 ID - Galanopoulos2017 ER - TY - JOUR AU - Quintero, E. AU - Castells, A. AU - Bujanda, L. AU - Cubiella, J. AU - Salas, D. AU - Lanas, Á. PY - 2012 DA - 2012// TI - Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening JO - N Engl J Med VL - 366 UR - https://doi.org/10.1056/NEJMoa1108895 DO - 10.1056/NEJMoa1108895 ID - Quintero2012 ER - TY - JOUR AU - Edge, S. B. AU - Compton, C. C. PY - 2010 DA - 2010// TI - The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM JO - Ann Surg Oncol VL - 17 UR - https://doi.org/10.1245/s10434-010-0985-4 DO - 10.1245/s10434-010-0985-4 ID - Edge2010 ER - TY - JOUR AU - Clemens, H. AU - Markus, S. AU - Martin, M. AU - Roland, G. AU - Richard, G. PY - 2013 DA - 2013// TI - A modified phenol-chloroform extraction method for isolating circulating cell free DNA of tumor patients JO - J Nucleic Acids Investig VL - 4 UR - https://doi.org/10.4081/jnai.2013.4282 DO - 10.4081/jnai.2013.4282 ID - Clemens2013 ER - TY - JOUR AU - Sham, P. AU - Bader, J. S. AU - Craig, I. AU - O’Donovan, M. AU - Owen, M. PY - 2002 DA - 2002// TI - DNA pooling: a tool for large-scale association studies JO - Nat Rev Genet VL - 3 UR - https://doi.org/10.1038/nrg930 DO - 10.1038/nrg930 ID - Sham2002 ER - TY - JOUR AU - Moran, S. AU - Arribas, C. AU - Esteller, M. PY - 2016 DA - 2016// TI - Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences JO - Epigenomics VL - 8 UR - https://doi.org/10.2217/epi.15.114 DO - 10.2217/epi.15.114 ID - Moran2016 ER - TY - JOUR PY - 2012 DA - 2012// TI - An integrated encyclopedia of DNA elements in the human genome JO - Nature VL - 489 UR - https://doi.org/10.1038/nature11247 DO - 10.1038/nature11247 ID - ref31 ER - TY - JOUR AU - Siggens, L. AU - Ekwall, K. PY - 2014 DA - 2014// TI - Epigenetics, chromatin and genome organization: recent advances from the ENCODE project JO - J Intern Med VL - 276 UR - https://doi.org/10.1111/joim.12231 DO - 10.1111/joim.12231 ID - Siggens2014 ER - TY - JOUR AU - Lizio, M. AU - Harshbarger, J. AU - Shimoji, H. AU - Severin, J. AU - Kasukawa, T. AU - Sahin, S. PY - 2015 DA - 2015// TI - Gateways to the FANTOM5 promoter level mammalian expression atlas JO - Genome Biol VL - 16 UR - https://doi.org/10.1186/s13059-014-0560-6 DO - 10.1186/s13059-014-0560-6 ID - Lizio2015 ER - TY - JOUR AU - Aryee, M. J. AU - Jaffe, A. E. AU - Corrada-Bravo, H. AU - Ladd-Acosta, C. AU - Feinberg, A. P. AU - Hansen, K. D. PY - 2014 DA - 2014// TI - Minfi: a flexible and comprehensive bioconductor package for the analysis of Infinium DNA methylation microarrays JO - Bioinformatics VL - 30 UR - https://doi.org/10.1093/bioinformatics/btu049 DO - 10.1093/bioinformatics/btu049 ID - Aryee2014 ER - TY - JOUR AU - Morris, T. J. AU - Butcher, L. M. AU - Feber, A. AU - Teschendorff, A. E. AU - Chakravarthy, A. R. AU - Wojdacz, T. K. PY - 2014 DA - 2014// TI - ChAMP: 450k chip analysis methylation pipeline JO - Bioinformatics VL - 30 UR - https://doi.org/10.1093/bioinformatics/btt684 DO - 10.1093/bioinformatics/btt684 ID - Morris2014 ER - TY - JOUR AU - Fortin, J. -. P. AU - Labbe, A. AU - Lemire, M. AU - Zanke, B. W. AU - Hudson, T. J. AU - Fertig, E. J. PY - 2014 DA - 2014// TI - Functional normalization of 450k methylation array data improves replication in large cancer studies JO - Genome Biol VL - 15 UR - https://doi.org/10.1186/s13059-014-0503-2 DO - 10.1186/s13059-014-0503-2 ID - Fortin2014 ER - TY - JOUR AU - Pidsley, R. AU - Zotenko, E. AU - Peters, T. J. AU - Lawrence, M. G. AU - Risbridger, G. P. AU - Molloy, P. PY - 2016 DA - 2016// TI - Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling JO - Genome Biol VL - 17 UR - https://doi.org/10.1186/s13059-016-1066-1 DO - 10.1186/s13059-016-1066-1 ID - Pidsley2016 ER - TY - JOUR AU - Du, P. AU - Zhang, X. AU - Huang, C. -. C. AU - Jafari, N. AU - Kibbe, W. A. AU - Hou, L. PY - 2010 DA - 2010// TI - Comparison of beta-value and M-value methods for quantifying methylation levels by microarray analysis JO - BMC Bioinformatics VL - 11 UR - https://doi.org/10.1186/1471-2105-11-587 DO - 10.1186/1471-2105-11-587 ID - Du2010 ER - TY - JOUR AU - Bibbins-Domingo, K. AU - Grossman, D. C. AU - Curry, S. J. AU - Davidson, K. W. AU - Epling, J. W. AU - García, F. A. R. PY - 2016 DA - 2016// TI - Screening for colorectal cancer JO - JAMA VL - 315 UR - https://doi.org/10.1001/jama.2016.5989 DO - 10.1001/jama.2016.5989 ID - Bibbins-Domingo2016 ER - TY - JOUR AU - Dedeurwaerder, S. AU - Defrance, M. AU - Calonne, E. AU - Denis, H. AU - Sotiriou, C. AU - Fuks, F. PY - 2011 DA - 2011// TI - Evaluation of the Infinium methylation 450K technology JO - Epigenomics VL - 3 UR - https://doi.org/10.2217/epi.11.105 DO - 10.2217/epi.11.105 ID - Dedeurwaerder2011 ER - TY - JOUR AU - Ehrlich, M. PY - 2009 DA - 2009// TI - DNA hypomethylation in cancer cells JO - Epigenomics VL - 1 UR - https://doi.org/10.2217/epi.09.33 DO - 10.2217/epi.09.33 ID - Ehrlich2009 ER - TY - JOUR AU - Goelz, S. E. AU - Vogelstein, B. AU - Hamilton, S. R. AU - Feinberg, A. P. PY - 1985 DA - 1985// TI - Hypomethylation of DNA from benign and malignant human colon neoplasms JO - Science VL - 228 UR - https://doi.org/10.1126/science.2579435 DO - 10.1126/science.2579435 ID - Goelz1985 ER - TY - JOUR AU - Okugawa, Y. AU - Grady, W. M. AU - Goel, A. PY - 2015 DA - 2015// TI - Epigenetic alterations in colorectal cancer: emerging biomarkers JO - Gastroenterology VL - 149 UR - https://doi.org/10.1053/j.gastro.2015.07.011 DO - 10.1053/j.gastro.2015.07.011 ID - Okugawa2015 ER - TY - STD TI - Timp W, Bravo HC, McDonald OG, Goggins M, Umbricht C, Zeiger M, et al. Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors. Genome Med. 2014;6 https://doi.org/10.1186/s13073-014-0061-y. ID - ref44 ER - TY - JOUR AU - Jung, K. AU - Fleischhacker, M. AU - Rabien, A. PY - 2010 DA - 2010// TI - Cell-free DNA in the blood as a solid tumor biomarker—a critical appraisal of the literature JO - Clin Chim Acta VL - 411 UR - https://doi.org/10.1016/j.cca.2010.07.032 DO - 10.1016/j.cca.2010.07.032 ID - Jung2010 ER - TY - JOUR AU - Roperch, J. P. AU - Incitti, R. AU - Forbin, S. AU - Bard, F. AU - Mansour, H. AU - Mesli, F. PY - 2013 DA - 2013// TI - Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer JO - BMC Cancer VL - 13 UR - https://doi.org/10.1186/1471-2407-13-566 DO - 10.1186/1471-2407-13-566 ID - Roperch2013 ER - TY - JOUR AU - Barault, L. AU - Amatu, A. AU - Siravegna, G. AU - Ponzetti, A. AU - Moran, S. AU - Cassingena, A. PY - 2017 DA - 2017// TI - Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer JO - Gut VL - 0 ID - Barault2017 ER - TY - JOUR AU - Heiss, J. A. AU - Brenner, H. PY - 2017 DA - 2017// TI - Epigenome-wide discovery and evaluation of leukocyte DNA methylation markers for the detection of colorectal cancer in a screening setting JO - Clin Epigenetics VL - 9 UR - https://doi.org/10.1186/s13148-017-0322-x DO - 10.1186/s13148-017-0322-x ID - Heiss2017 ER -