Clinical Epigenetics

Table 1 Distribution of methylation status by selected epidemiologic and clinical characteristics

From: The neuropeptide genes SST, TAC1, HCRT, NPY, and GAL are powerful epigenetic biomarkers in head and neck cancer: a site-specific analysis

Characteristics					Age				Gender					Smoking status
Gene	Methylation status		Overall(%)		< 65	> 65		P ^†	Female		Male	P ^†		Smoker	Non-smoker		P ^†
SST	Yes		194(84.3)		81	113			29		165			146	48
SST	No		36(15.7)		17	19		1	8		28	1		26	10		1
TAC1	Yes		146(63.5)		59	87			18		128			118	28
TAC1	No		84(36.5)		39	45		1	19		65	0.061		54	30		0.007*
HCRT	Yes		75(32.6)		35	40			7		68			52	23
HCRT	No		155(67.4)		63	92		1	30		125	0.057		120	35		1
NPY	Yes		65(28.3)		24	41			11		54			44	21
NPY	No		165(71.7)		74	91		0.302	26		139	1		128	37		1
GAL	Yes		46(20.0)		19	27			14		32			30	16
GAL	No		184(80.0)		79	105		0.869	23		161	1		143	42		1
Characteristics			Alcohol exposure			Tumor size			Lymph node status			Stage			Recurrence events
Gene	Methylation status	Overall(%)	Drinker	Non-drinker	P ^†	T1–2	T3–4	P ^†	N0	N+	P ^†	I, II, III	IV	P ^†	Positive	Negative	P ^†
SST	Yes	194(84.3)	140	54		95	99		80	114		86	108		78	116
	No	36(15.7)	25	11	1	16	20	0.717	19	17	0.206	17	19	1	13	23	0.713
TAC1	Yes	146(63.5)	112	34		70	76		59	87		64	82		65	81
	No	84(36.5)	53	31	1	41	43	1	40	44	1	39	45	1	26	58	0.051
HCRT	Yes	75(32.6)	55	20		39	36		28	47		30	45		37	38
	No	155(67.4)	110	45	0.756	72	83	0.482	71	84	0.257	73	82	0.326	54	101	1
NPY	Yes	65(28.3)	44	21		37	28		32	33		30	35		26	39
	No	165(71.7)	121	44	1	74	91	0.109	67	98	1	73	92	1	65	100	1
GAL	Yes	46(20.0)	25	21		23	23		18	28		20	26		27	19
	No	184(80.0)	140	44	1	88	96	1	81	103	0.619	83	101	0.87	64	120	0.004*

*P < 0.05
†Chi-squared test

Back to article page

ISSN: 1868-7083

Contact us

Submission enquiries: avalyn.villar@springernature.com
General enquiries: info@biomedcentral.com