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Table 3 The results of cis-methylation quantitative trait loci for cg06500161 in ABCG1 gene

From: Epigenome-wide association study of metabolic syndrome in African-American adults

CpG SNP Effect allele β SNP-CpG SE SNP-CpG p value of SNP-CpG OR SNP-MetS SE SNP-MetS p value of SNP-MetS
cg06500161 rs9978671 C − 0.0203 0.0030 9.98 × 10−10 1.13 0.07 0.08
cg06500161 rs17114493 T − 0.0264 0.0050 7.20 × 10−7 1.22 0.07 4.30 × 10 −3
cg06500161 rs4547619 C − 0.0264 0.0050 7.20 × 10−7 1.22 0.07 4.30 × 10 −3
cg06500161 rs225440 C 0.0123 0.0025 2.96 × 10−6 0.91 0.07 0.19
cg06500161 rs225448 T 0.0123 0.0025 4.16 × 10−6 0.88 0.07 0.06
cg06500161 rs2839475 A − 0.0220 0.0046 5.38 × 10−6 1.22 0.07 5.94 × 10 −3
cg06500161 rs1824010 C −0.0222 0.0048 9.93 × 10−6 1.20 0.07 8.98 × 10 −3
cg06500161 rs8130198 A − 0.0222 0.0048 9.93 × 10−6 1.20 0.07 8.98 × 10 −3
cg06500161 rs8134682 T − 0.0222 0.0048 9.93 × 10−6 1.20 0.07 8.98 × 10 −3
cg06500161 rs8129752 A − 0.0225 0.0049 1.27 × 10−5 1.21 0.07 6.47 × 10 −3
cg06500161 rs7283699 G − 0.0131 0.0029 1.51 × 10−5 1.13 0.07 0.08
cg06500161 rs9974658 G − 0.0131 0.0031 4.65 × 10− 5 1.11 0.07 0.17
cg06500161 rs915847 G 0.0118 0.0028 4.97 × 10−5 0.99 0.07 0.84
cg06500161 rs12329683 T − 0.0130 0.0031 6.80 × 10−5 1.09 0.07 0.22
cg06500161 rs9982196 T − 0.0120 0.0029 7.61 × 10−5 1.12 0.07 0.13
cg06500161 rs9978842 C − 0.0144 0.0036 1.03 × 10−4 1.12 0.07 0.13
  1. Linear mixed models were used for SNP-CpG association with CpG β score as the outcome adjusted for age, sex, study site, ancestry principal components, cell counts, and familial relationship. Logistic mixed models were used for SNP-MetS association with MetS as the outcome adjusted for age, sex, center, first four PCs, and familial relationship
  2. MetS metabolic syndrome