Epigenome-wide association study of metabolic syndrome in African-American adults

Clinical Epigenetics

Table 3 The results of cis-methylation quantitative trait loci for cg06500161 in ABCG1 gene

CpG	SNP	Effect allele	β SNP-CpG	SE SNP-CpG	p value of SNP-CpG	OR SNP-MetS	SE SNP-MetS	p value of SNP-MetS
cg06500161	rs9978671	C	− 0.0203	0.0030	9.98 × 10⁻¹⁰	1.13	0.07	0.08
cg06500161	rs17114493	T	− 0.0264	0.0050	7.20 × 10⁻⁷	1.22	0.07	4.30 × 10 ⁻³
cg06500161	rs4547619	C	− 0.0264	0.0050	7.20 × 10⁻⁷	1.22	0.07	4.30 × 10 ⁻³
cg06500161	rs225440	C	0.0123	0.0025	2.96 × 10⁻⁶	0.91	0.07	0.19
cg06500161	rs225448	T	0.0123	0.0025	4.16 × 10⁻⁶	0.88	0.07	0.06
cg06500161	rs2839475	A	− 0.0220	0.0046	5.38 × 10⁻⁶	1.22	0.07	5.94 × 10 ⁻³
cg06500161	rs1824010	C	−0.0222	0.0048	9.93 × 10⁻⁶	1.20	0.07	8.98 × 10 ⁻³
cg06500161	rs8130198	A	− 0.0222	0.0048	9.93 × 10⁻⁶	1.20	0.07	8.98 × 10 ⁻³
cg06500161	rs8134682	T	− 0.0222	0.0048	9.93 × 10⁻⁶	1.20	0.07	8.98 × 10 ⁻³
cg06500161	rs8129752	A	− 0.0225	0.0049	1.27 × 10⁻⁵	1.21	0.07	6.47 × 10 ⁻³
cg06500161	rs7283699	G	− 0.0131	0.0029	1.51 × 10⁻⁵	1.13	0.07	0.08
cg06500161	rs9974658	G	− 0.0131	0.0031	4.65 × 10^− 5	1.11	0.07	0.17
cg06500161	rs915847	G	0.0118	0.0028	4.97 × 10⁻⁵	0.99	0.07	0.84
cg06500161	rs12329683	T	− 0.0130	0.0031	6.80 × 10⁻⁵	1.09	0.07	0.22
cg06500161	rs9982196	T	− 0.0120	0.0029	7.61 × 10⁻⁵	1.12	0.07	0.13
cg06500161	rs9978842	C	− 0.0144	0.0036	1.03 × 10⁻⁴	1.12	0.07	0.13

Linear mixed models were used for SNP-CpG association with CpG β score as the outcome adjusted for age, sex, study site, ancestry principal components, cell counts, and familial relationship. Logistic mixed models were used for SNP-MetS association with MetS as the outcome adjusted for age, sex, center, first four PCs, and familial relationship
MetS metabolic syndrome

ISSN: 1868-7083