Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study

Table 2 Marginal correlations between lipid and other biomarkers with epigenetic age acceleration in the GOLDN study

	Horvath age acceleration		Hannum age acceleration (EEAA)
	r	p	r	p
Lipids
LDL mg/dL (0 h)	0.11	0.0008	0.11	0.002
LDL mg/dL (6 h)	0.12	0.0009	0.10	0.003
HDL mg/dL (0 h)	− 0.02	0.50	− 0.13	0.0002
HDL mg/dL (6 h)	− 0.01	0.83	− 0.12	0.0004
TC mg/dL (0 h)	0.12	0.0004	0.08	0.02
TC mg/dL (6 h)	0.14	< .0001	0.09	0.007
TG mg/dL (0 h)	0.11	0.001	0.11	0.002
TG mg/dL (6 h)	0.17	< .0001	0.15	< .0001
Inflammatory markers
IL6 (0 h)	0.05	0.18	0.09	0.02
CRP (0 h)	0.04	0.25	0.06	0.09
MCP1 (0 h)	0.01	0.81	0.07	0.05
IL2SRA (0 h)	−0.01	0.84	0.08	0.01
Adiponectin (0 h)	− 0.08	0.03	− 0.07	0.05
TNFα (0 h)	0.05	0.16	0.11	0.002

EEAA extrinsic epigenetic age acceleration, 0 h fasting time point, 6 h postprandial time point

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