Table 1 Descriptive statistics of the GOLDN study population categorized by the median of two age acceleration residuals
| Â | Horvath age acceleration | Hannum age acceleration (EEAA) | ||||
|---|---|---|---|---|---|---|
N (%) or mean (SD) | Below median | Above median | p | Below median | Above median | p |
Center (UT) | 220 (53.0) | 153 (36.9) | < 0.0001 | 223 (46.2) | 192 (43.6) | 0.44 |
Female | 226 (54.5) | 193 (46.5) | 0.02 | 222 (53.5) | 197 (47.5) | 0.08 |
Current smoker | 34 (8.2) | 35(8.4) | 0.89 | 32 (7.7) | 37 (8.9) | 0.52 |
Current drinking | 201 (48.4) | 238 (57.4) | 0.01 | 228(54.9) | 211 (50.8) | 0.23 |
History of CHD | 16 (3.9) | 27 (6.5) | 0.08 | 15 (3.6) | 28 (6.8) | 0.04 |
Hypertension | 99 (23.9) | 121 (29.2) | 0.08 | 89 (21.5) | 131 (31.6) | 0.001 |
Diabetes | 22 (5.3) | 41 (9.8) | 0.01 | 23 (5.5) | 40 (9.6) | 0.03 |
Age | 46.6 (16.2) | 50.7 (15.5) | 0.0002 | 46.6 (16.1) | 50.7 (15.6) | 0.0002 |
Lipids | ||||||
 LDL mg/dL (0 h) | 114.9 (31.8) | 121.7 (32.2) | 0.003 | 116.5 (31.8) | 120.1 (32.4) | 0.10 |
 LDL mg/dL (6 h) | 119.2(32.1) | 125.9 (33.2) | 0.003 | 120.8 (32.2) | 124.4 (33.3) | 0.12 |
 HDL mg/dL (0 h) | 46.0 (14.1) | 44.5 (13.1) | 0.12 | 47.1 (14.5) | 43.4 (12.4) | < 0.0001 |
 HDL mg/dL (6 h) | 48.8 (14.6) | 47.8 (14.1) | 0.34 | 50.2 (15.2) | 46.3 (133) | < 0.0001 |
 TC mg/dL (0 h) | 181.6 (38.4) | 189.7 (40.0) | 0.003 | 183.9 (38.8) | 187.4(39.9) | 0.20 |
 TC mg/dL (6 h) | 189.2 (39.6) | 199.0 (42.9) | 0.0007 | 191.9 (40.3) | 196.3 (42.7) | 0.13 |
 TG mg/dL (0 h) | 135.5 (84.8) | 155.5 (108.5) | 0.003 | 133.4 (83.0) | 157.8 (109.5) | 0.0003 |
 TG mg/dL (6 h) | 187.9 (130.5) | 230.8 (166.8) | < 0.0001 | 187.0 (129.7) | 231.8 (167.3) | < 0.0001 |
Inflammatory markers | ||||||
 IL6 | 1.9 (2.2) | 2.2 (4.4) | 0.11 | 1.8 (26) | 2.2 (4.2) | 0.08 |
 CRP | 0.21 (0.3) | 0.25 (0.4) | 0.22 | 0.20 (0.4) | 0.26 (0.4) | 0.03 |
 MCP1 | 207.8 (62.5) | 211.2 (68.7) | 0.45 | 204.3 (64.9) | 214.7 (66.1) | 0.02 |
 IL2SRA | 1012.3 (344.5) | 1021.2 (377.1) | 0.72 | 991.2 (330.3) | 1042.3 (388.0) | 0.04 |
 Adiponectin | 8498.6 (4644.7) | 8047.9 (4827.6) | 0.17 | 8568.1 (4746.8) | 7978.2 (4719.4) | 0.07 |
 TNFα | 3.2 (1.9) | 3.9 (8.0) | 0.08 | 3.1 (1.8) | 4.0 (8.0) | 0.02 |