Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes

Table 3 Significant ASM associations with rs174537 in CD4+ cell-derived samples from cohort 2

Location	CpG site	Estimate	Std. Err.	R ²	Raw p value	FDR p value
FADS1 promoter	chr11:61584836	− 0.009	0.007	0.19	1.91E−01	3.18E−01
FADS1 promoter	chr11:61584894*	− 0.050	0.016	0.37	6.78E−03	3.70E−02
Putative enhancer region	chr11:61587979 (cg27386326)	0.052	0.087	0.06	5.57E−01	6.40E−01
FADS2 promoter	chr11:61594865	− 0.075	0.037	0.33	5.33E−02	1.78E−01
	chr11:61594876*	− 0.101	0.034	0.43	7.46E−03	3.70E−02
	chr11:61594907	− 0.069	0.044	0.35	1.31E−01	2.88E−01

Genetic trend test adjusted for age and gender revealed significant ASM associations (*FDR p value < 0.05) with DNA methylation quantitated from whole blood-derived CD4+ cells

ISSN: 1868-7083