Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes

Table 2 Significant ASM associations with rs174537 in leukocyte-derived samples from cohort 1

Location	CpG site	Estimate	Std. Err.	R ²	Raw p value	FDR p value
FADS1 promoter	chr11:61584836	0.001	0.002	0.03	4.83E−01	4.83E−01
FADS1 promoter	chr11:61584894	− 0.010	0.005	0.07	6.08E−02	7.29E−02
Putative enhancer region	chr11:61587979* (cg27386326)	0.038	0.016	0.07	2.54E−02	3.80E−02
FADS2 promoter	chr11:61594865*	− 0.029	0.009	0.14	9.29E−04	1.86E−03
	chr11:61594876*	− 0.047	0.008	0.27	3.07E−07	9.20E−07
	chr11:61594907*	− 0.051	0.009	0.27	2.52E−07	9.20E−07

Genetic trend test adjusted for age and gender revealed significant ASM associations (*FDR p value < 0.05) with DNA methylation quantitated from whole blood-derived total leukocytes

ISSN: 1868-7083