UPN | Time from diagnosis | Status | Chromosome change | DNMT3A mutation (VAF, %) | Other mutations (VAF, %) |
---|---|---|---|---|---|
1 | 0Â month | MDS-EB2 | N | R882H (41.3) | NRAS (38.4), RUNX1 (39), SF3B1 (38.8) |
6.5Â months | AML | ND | R882H (28.5) | NRAS (29.1), RUNX1 (26.7), SF3B1 (28.3) | |
5 | 0Â month | MDS-EB2 | N | R882H (25.2) | CEBPA (23.5) |
5Â months | AML | N | R882H (41.8) | CEBPA (38.3) | |
7 | 0Â month | MDS-EB2 | N | R882H (34.2) | RUNX1 (30.3), IDH2 (32.8), SF3B1 (32.5) |
9Â months | AML (s/p C/T) | N | R882H (27.4) | RUNX1 (28.6), IDH2 (27.6), SF3B1 (28.3) | |
10 | 0Â month | MDS-EB1 | N | L723TfsX56 (17.1), 1554+1G>T (17) | U2AF1 (16.5), RUNX1 (9.8) |
7Â months | MDS-EB1 | N | L723TfsX56 (6.3), 1554+1G>T (6.3) | U2AF1 (6.4), RUNX1 (3.6) | |
13 | 0Â month | MDS-EB1 | N | R882H (12.4) | MLL-PTD |
7 months | AML | + 8 | R882H (20.9) | MLL-PTD | |
9Â months | s/p C/T in CR | N | R882H* | MLL-PTD | |
17 | 0Â month | RAEB-T | N | R882H (35.3) | IDH2 (7.6), NPM1 (39.5) |
19.5 months | s/p allo-HSCT | N | – | – | |
21 | 0Â month | RARS | N | Y735C (34.5) | SF3B1 (44.4), TET2 (42.3) |
34Â months | RARS | N | Y735C (31.1) | SF3B1 (44), TET2 (44.3) | |
23 | 0Â month | RA | N | W313X (45.24), W860R (45.55) | ASXL1 (35.12), IDH2 (48.19) |
3.5Â months | CMML | N | W313X (47.74), W860R (44.6) | ASXL1 (33.31), IDH2 (45.29) | |
24 | 0Â month | MDS-EB1 | inv(9)(p11q12) | R882H (8.4) | NPM1 (7) |
7.5Â months | AML | inv(9)(p11q12) | R882H(33.8) | NPM1 (31.3) | |
12 months | s/p C/T | inv(9)(p11q12) | – | – | |
20 months | s/p allo-HSCT | ND | – | – | |
27 | 0Â month | RARS | N | L508SfsX143 (41.1) | SF3B1 (39.9), TET2 (42.6) |
43.5Â months | RARS | N | L508SfsX143 (39.9) | SF3B1 (39.2), TET2 (41.2) | |
30 | 0 month | MDS-EB2 | − 7 | R882C (30.5) | U2AF1 (29.2) |
13.5 months | s/p allo-HSCT | N | – | – | |
36 | 0 month | MDS-EB1 | der(7)t(1;7)(q12;q11),+ 21 | R882C (25.4) | – |
9.5 months | MDS-EB2 | der(7)t(1;7)(q12;q11),+ 21 | R882C (19) | – | |
13.5 months | s/p allo-HSCT | N | – | – | |
37 | 0Â month | RARS | N | R882H (38.2) | SF3B1 (38.2), TET2 (41.7) |
7Â months | AML | N | R882H (43.4) | RUNX1 (21.6), SF3B1 (43), TET2 (45.9) | |
47 | 0 month | MDS-EB1 | N | –** | – |
19Â months | MDS-EB1 | N | N838D (39.7) | GNAS (36.5), ASXL1 (17.3), ASXL1 (9), ZRSR2 (6) |