Fig. 4
From: Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC
Association between DNA methylation at sites cg11637544 in KDM2A and cg26662347 in KDM1A with overall survival of squamous cell carcinomas and correlation between these two sites and their corresponding gene expression. Fixed-effects meta-analysis was used to combine the results from discovery and validation sets for squamous cell carcinomas (SCC) (a cg11637544 KDM2A ; b cg26662347 KDM1A ). I2and corresponding P value were used to evaluate heterogeneity across studies. DNA methylation level was categorized to six quantiles, and box plot for gene expression was drawn for each quantile. Pearson correlation was used to estimate the correlation coefficient (r) and the P value; gene expression was log2 transformed before analysis (c cg11637544 KDM2A ; d cg26662347 KDM1A )