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Table 2 Associations between the valid CpG methylation in placenta and risk of FT-LBW

From: Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls

FGFR2 CpG sites FT-LBW FT-NBW Odds ratio for per standard deviation increment in DNA methylation (95% CI)a P value
N Mean (SD) N Mean (SD)
All subjects
 CpG 2 65 0.35 (0.20) 65 0.37 (0.22) 0.95 (0.66, 1.37) 0.77
 CpG 3.4 82 0.37 (0.08) 78 0.36 (0.08) 1.09 (0.78, 1.52) 0.62
 CpG 5 73 0.48 (0.13) 65 0.48 (0.13) 1.09 (0.76, 1.55) 0.64
 CpG 7 69 0.19 (0.13) 64 0.18 (0.11) 1.13 (0.76, 1.67) 0.54
 CpG 11 69 0.39 (0.11) 55 0.35 (0.09) 1.64 (1.07, 2.52) 0.02
Girls
 CpG 2 40 0.33 (0.20) 35 0.39 (0.23) 0.85 (0.52, 1.37) 0.49
 CpG 3.4 49 0.37 (0.08) 44 0.36 (0.07) 1.35 (0.84, 2.18) 0.49
 CpG 5 44 0.49 (0.10) 39 0.47 (0.14) 1.19 (0.73, 1.95) 0.49
 CpG 7 44 0.20 (0.15) 34 0.18 (0.11) 1.23 (0.72, 2.09) 0.45
 CpG 11 43 0.40 (0.11) 32 0.34 (0.11) 1.92 (1.07, 3.43) 0.02
Boys
 CpG 2 25 0.37 (0.19) 30 0.33 (0.22) 1.32 (0.68, 2.57) 0.42
 CpG 3.4 33 0.36 (0.09) 34 0.37 (0.08) 0.75 (0.43, 1.29) 0.29
 CpG 5 29 0.47 (0.15) 26 0.49 (0.12) 0.84 (0.48, 1.47) 0.54
 CpG 7 25 0.18 (0.10) 30 0.18 (0.12) 0.86 (0.42, 1.75) 0.67
 CpG 11 26 0.38 (0.12) 23 0.36 (0.05) 1.14 (0.52, 2.48) 0.74
  1. aIn all subjects, the models were adjusted for maternal age, education, family monthly income, ETS exposure during pregnancy, gestational age and newborn’s sex. In girls and boys, the models were adjusted for all the covariates mentioned above, except the newborn’s sex