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Table 2 Associations between the valid CpG methylation in placenta and risk of FT-LBW

From: Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls

FGFR2 CpG sites

FT-LBW

FT-NBW

Odds ratio for per standard deviation increment in DNA methylation (95% CI)a

P value

N

Mean (SD)

N

Mean (SD)

All subjects

 CpG 2

65

0.35 (0.20)

65

0.37 (0.22)

0.95 (0.66, 1.37)

0.77

 CpG 3.4

82

0.37 (0.08)

78

0.36 (0.08)

1.09 (0.78, 1.52)

0.62

 CpG 5

73

0.48 (0.13)

65

0.48 (0.13)

1.09 (0.76, 1.55)

0.64

 CpG 7

69

0.19 (0.13)

64

0.18 (0.11)

1.13 (0.76, 1.67)

0.54

 CpG 11

69

0.39 (0.11)

55

0.35 (0.09)

1.64 (1.07, 2.52)

0.02

Girls

 CpG 2

40

0.33 (0.20)

35

0.39 (0.23)

0.85 (0.52, 1.37)

0.49

 CpG 3.4

49

0.37 (0.08)

44

0.36 (0.07)

1.35 (0.84, 2.18)

0.49

 CpG 5

44

0.49 (0.10)

39

0.47 (0.14)

1.19 (0.73, 1.95)

0.49

 CpG 7

44

0.20 (0.15)

34

0.18 (0.11)

1.23 (0.72, 2.09)

0.45

 CpG 11

43

0.40 (0.11)

32

0.34 (0.11)

1.92 (1.07, 3.43)

0.02

Boys

 CpG 2

25

0.37 (0.19)

30

0.33 (0.22)

1.32 (0.68, 2.57)

0.42

 CpG 3.4

33

0.36 (0.09)

34

0.37 (0.08)

0.75 (0.43, 1.29)

0.29

 CpG 5

29

0.47 (0.15)

26

0.49 (0.12)

0.84 (0.48, 1.47)

0.54

 CpG 7

25

0.18 (0.10)

30

0.18 (0.12)

0.86 (0.42, 1.75)

0.67

 CpG 11

26

0.38 (0.12)

23

0.36 (0.05)

1.14 (0.52, 2.48)

0.74

  1. aIn all subjects, the models were adjusted for maternal age, education, family monthly income, ETS exposure during pregnancy, gestational age and newborn’s sex. In girls and boys, the models were adjusted for all the covariates mentioned above, except the newborn’s sex