Table 3 CpG site-specific regression models before and after normalization step
From: Identifying and correcting epigenetics measurements for systematic sources of variation
Values | Methods | Significant sitesb | CHARGEc | Sensitivity | 1-Specificity |
|---|---|---|---|---|---|
β values | Standard adjustmenta | 444 | 357 (80%) | 1.9×10−2 | 2.2×10−4 |
Residuals | 427 | 365 (85%) | 1.9×10− 2 | 1.5×10− 4 | |
ComBat | 600 | 411 (69%) | 2.2×10− 2 | 4.7×10− 4 | |
SVA | 96 | 89 (92%) | 0.5×10−2 | 0.2×10−4 | |
M values | Standard adjustmenta | 322 | 274 (85%) | 1.5×10−2 | 1.2×10−4 |
Residuals | 332 | 299 (90%) | 1.6×10−2 | 0.8×10−4 | |
ComBat | 387 | 335 (87%) | 1.8×10−2 | 1.3×10−4 | |
SVA | 144 | 134 (93%) | 0.7×10−2 | 0.2×10−4 |