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Fig. 7 | Clinical Epigenetics

Fig. 7

From: Neonatal exposure to hyperoxia leads to persistent disturbances in pulmonary histone signatures associated with NOS3 and STAT3 in a mouse model

Fig. 7

Response to hypoxia after previous treatment with TSA. a eNOS expression. b STAT3α expression. c HIF (hypoxia inducible factor) expression. d H3K9ac. e H3K27me3. HAEC were either treated with TSA twice for 6 h with an interval of 60 h (light gray) or once for 72 h (white). After culture under normal conditions for 26 days, cells were then subjected to hypoxia (ppO2 of 0.1 bar for 24 h). Histone modifications were analyzed at the promoter region. All experiments were performed three times with three different HAEC lines. Error bars indicated 95% CI. Asterisks indicate significant differences (p < 0.05)

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