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Table 4 Genome-wide measures of altered DNAm in high-risk MTHFR and reference placentas

From: No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation

  Array-wide average DNAm (β) Outlier array sites (%) Alu DNAm (%) LINE-1 DNAm (%) rDNAm (%)
Reference (N = 10) 0.407 (0.396–0.413) 0.661 (0.262–0.993) 18.9 (17.6–21.7) 52.8 (51.0–53.8) 19.4 (11.2–30.9)
High-risk 677 (N = 10) 0.405 (0.397–0.409) 0.851 (0.262–6.357) 20.1 (15.7–21.4) 53.5 (49.8–57.6) 20.0 (8.4–28.9)
High-risk 1298 (N = 10) 0.405 (0.395–0.413) 1.14 (0.501–3.37) 19.8 (17.5–21.6) 51.0 (46.5–55.0) 22.9 (10.2–28.9)
  1. All results are reported as median (range); p values were calculated by the Mann-Whitney test for the comparison of high-risk 677 or high-risk 1298 to the reference group with Bonferroni correction for multiple comparisons
  2. β beta value, rDNAm ribosomal RNA genes