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Table 1 Clinical characteristics of cases

From: No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation

  N Sex; N male (% male) Gestational age (weeks); median (range) Maternal age (years); median (range)
Control 179 85 (47) 39.6 (19.4–41.9) 34.4 (23.8–42.7)
EOPE 28 17 (61) 32.7 (23.6–38.4)* 36.0 (19.7–42.9)
LOPE 20 10 (50) 38.5 (34.9–41.4)* 34.3 (26.1–41.5)
nIUGR 21 9 (42) 36.2 (24.0–40.6)* 34.5 (26.1–42.8)
NTD 55 28 (51) 21.0 (16.7–23.7)* 30.4 (17.7–40.6)*
  1. EOPE early-onset preeclampsia, LOPE late-onset preeclampsia, nIUGR normotensive intrauterine growth restriction, NTD neural tube defect
  2. *p < 0.05, calculated in comparison to the control group by Fisher’s exact test for categorical variables and Mann-Whitney test for continuous variables