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Table 1 Donor demographics

From: Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

  Airway fibroblasts Parenchymal fibroblasts  
  Non-COPD COPD Non-COPD vs COPD p value Non-COPD COPD Non-COPD vs COPD p value Airway vs parenchymal COPD p value
N 8 7   17 29   
Gender (M/F) 2/6 6/1 0.0187 9/8 18/11 0.544 0.2336
Age
Mean (SD)
63.36 (10.06) 68 (5.63) 0.3097 65.06 (11.31) 65.1 (9.60) 0.9994 0.4489
Pack-years
Mean (SD)
21.6 (18.89) 53.4 (29.84) 0.0221 31.8 (25.52) 39.8 (19.94) 0.3345 0.1798
FEV1%
Mean (SD)
100.8 (11) 69.7 (18.5) 0.0046 95.6 (17.2) 47.8 (26.3) < 0.0001 0.0457
FEV1/FVC %
Mean (SD)
77.42 (7.2) 59.8 (12) 0.0035 76.6 (6.4) 44.8 (15.5) < 0.0001 0.0182
GOLD stage NA 2× GS1, 3× GS2, 2× GS3 NA NA 3× GS1, 10× GS2, 3× GS3, 13× GS4 NA NA
  1. M male, F female, COPD chronic obstructive pulmonary disease, SD standard deviation, FEV forced expiratory volume, FVC forced vital capacity, NA not applicable