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Table 1 Donor demographics

From: Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

 

Airway fibroblasts

Parenchymal fibroblasts

 
 

Non-COPD

COPD

Non-COPD vs COPD p value

Non-COPD

COPD

Non-COPD vs COPD p value

Airway vs parenchymal COPD p value

N

8

7

 

17

29

  

Gender (M/F)

2/6

6/1

0.0187

9/8

18/11

0.544

0.2336

Age

Mean (SD)

63.36 (10.06)

68 (5.63)

0.3097

65.06 (11.31)

65.1 (9.60)

0.9994

0.4489

Pack-years

Mean (SD)

21.6 (18.89)

53.4 (29.84)

0.0221

31.8 (25.52)

39.8 (19.94)

0.3345

0.1798

FEV1%

Mean (SD)

100.8 (11)

69.7 (18.5)

0.0046

95.6 (17.2)

47.8 (26.3)

< 0.0001

0.0457

FEV1/FVC %

Mean (SD)

77.42 (7.2)

59.8 (12)

0.0035

76.6 (6.4)

44.8 (15.5)

< 0.0001

0.0182

GOLD stage

NA

2× GS1, 3× GS2, 2× GS3

NA

NA

3× GS1, 10× GS2, 3× GS3, 13× GS4

NA

NA

  1. M male, F female, COPD chronic obstructive pulmonary disease, SD standard deviation, FEV forced expiratory volume, FVC forced vital capacity, NA not applicable