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Table 1 Top 20 significantly differentially methylated sites in transcriptional cluster 2 placentas (N = 19) compared to transcriptional cluster 1 placentas (N = 19), corrected for fetal sex and gestational age at delivery

From: Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia

Probe Delta M Average M Delta β Average β FDR q value Gene(s) Location(s)a Enhancer Groupb
cg10900537 0.41 2.75 0.03 0.87 9.93E-04 FOXN3 Body-open sea True No
cg18498598 0.35 1.80 0.03 0.78 2.15E-03 CUX1 Body-open sea False No
cg11235787 0.36 1.72 0.04 0.77 2.15E-03 MIR195 Body-shelf False Yes
cg17850498c − 0.93 1.58 − 0.14 0.74 2.15E-03 ECE1 Body-open sea True No
cg01938025 0.62 2.62 0.05 0.86 2.15E-03 SKI Body-shelf False No
cg22807822 0.61 3.49 0.03 0.92 2.15E-03 KANK2 Body-shore False Yes
cg14601621 0.54 1.79 0.08 0.77 2.15E-03 C9orf3 3′UTR-island False Yes
cg00483891 − 0.55 1.90 − 0.06 0.79 2.15E-03 CCDC115 Body-shore False No
cg10994126 − 0.63 − 0.23 − 0.13 0.46 2.92E-03 PAPPA2 1stExon-open sea False No
cg17107691 0.76 3.14 0.05 0.89 2.92E-03 KANK2 Body-shore False Yes
cg01412654 −0.56 −0.38 −0.11 0.44 2.92E-03 PPARG TSS1500-shore False No
cg05359207 −0.52 −2.62 − 0.05 0.14 2.92E-03 ZNF217 Body-shore False No
cg06917772 −0.35 −1.33 − 0.06 0.29 2.92E-03 MIR3167 IGR-shore True No
cg24787238 0.34 1.29 0.04 0.71 2.92E-03 MAD1L1 Body-open sea True No
cg21564965 0.53 4.73 0.01 0.96 2.92E-03 ARHGAP23 Body-open sea False No
cg13562353 −0.53 1.40 −0.09 0.72 2.92E-03 CCL27 TSS200-shelf False No
cg26897909 0.45 1.85 0.04 0.78 2.92E-03 SRGAP2 Body-open sea True No
cg09106999 −0.44 −2.01 −0.05 0.20 2.92E-03 CDK2 SILV PMEL TSS1500-shore TSS1500-shore TSS1500-shore False No
cg02006426 −0.39 −0.23 −0.05 0.46 2.92E-03 DYSF IGR-shore False No
cg19431235 0.36 1.79 0.04 0.78 2.92E-03 DIAPH3 Body-open sea True No
  1. aTSS transcription start site, IGR intergenic region, UTR untranslated region
  2. bIncluded in a group of at least three significantly differentially methylated positions within the span of 1000 base pairs
  3. cAlso significantly differentially methylated in cluster 3 compared to cluster 1