Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia

Clinical Epigenetics

Table 1 Top 20 significantly differentially methylated sites in transcriptional cluster 2 placentas (N = 19) compared to transcriptional cluster 1 placentas (N = 19), corrected for fetal sex and gestational age at delivery

Probe	Delta M	Average M	Delta β	Average β	FDR q value	Gene(s)	Location(s)^a	Enhancer	Group^b
cg10900537	0.41	2.75	0.03	0.87	9.93E-04	FOXN3	Body-open sea	True	No
cg18498598	0.35	1.80	0.03	0.78	2.15E-03	CUX1	Body-open sea	False	No
cg11235787	0.36	1.72	0.04	0.77	2.15E-03	MIR195	Body-shelf	False	Yes
cg17850498^c	− 0.93	1.58	− 0.14	0.74	2.15E-03	ECE1	Body-open sea	True	No
cg01938025	0.62	2.62	0.05	0.86	2.15E-03	SKI	Body-shelf	False	No
cg22807822	0.61	3.49	0.03	0.92	2.15E-03	KANK2	Body-shore	False	Yes
cg14601621	0.54	1.79	0.08	0.77	2.15E-03	C9orf3	3′UTR-island	False	Yes
cg00483891	− 0.55	1.90	− 0.06	0.79	2.15E-03	CCDC115	Body-shore	False	No
cg10994126	− 0.63	− 0.23	− 0.13	0.46	2.92E-03	PAPPA2	1stExon-open sea	False	No
cg17107691	0.76	3.14	0.05	0.89	2.92E-03	KANK2	Body-shore	False	Yes
cg01412654	−0.56	−0.38	−0.11	0.44	2.92E-03	PPARG	TSS1500-shore	False	No
cg05359207	−0.52	−2.62	− 0.05	0.14	2.92E-03	ZNF217	Body-shore	False	No
cg06917772	−0.35	−1.33	− 0.06	0.29	2.92E-03	MIR3167	IGR-shore	True	No
cg24787238	0.34	1.29	0.04	0.71	2.92E-03	MAD1L1	Body-open sea	True	No
cg21564965	0.53	4.73	0.01	0.96	2.92E-03	ARHGAP23	Body-open sea	False	No
cg13562353	−0.53	1.40	−0.09	0.72	2.92E-03	CCL27	TSS200-shelf	False	No
cg26897909	0.45	1.85	0.04	0.78	2.92E-03	SRGAP2	Body-open sea	True	No
cg09106999	−0.44	−2.01	−0.05	0.20	2.92E-03	CDK2 SILV PMEL	TSS1500-shore TSS1500-shore TSS1500-shore	False	No
cg02006426	−0.39	−0.23	−0.05	0.46	2.92E-03	DYSF	IGR-shore	False	No
cg19431235	0.36	1.79	0.04	0.78	2.92E-03	DIAPH3	Body-open sea	True	No

^aTSS transcription start site, IGR intergenic region, UTR untranslated region
^bIncluded in a group of at least three significantly differentially methylated positions within the span of 1000 base pairs
^cAlso significantly differentially methylated in cluster 3 compared to cluster 1

ISSN: 1868-7083