Fig. 1

a Schematic overview of the trimeric complex comprising UHRF1, USP7, and DNMT1. Involved protein interactions and protein domains according to Felle et al. are shown [11]. b, c Chromatin immunoprecipitation (ChIP) was performed with HUH6 cells and the indicated antibodies. The average of two independent ChIP experiments for b DNMT1, UHRF1, and USP7 as well as c H3K9me2, H3K4me2, and RNAPII is shown. Standard deviations, genes of interest, and antibodies used for ChIP are indicated. The enrichment of specific IP versus IgG background is plotted