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Table 2 Mean observed CpG site methylation in vascular smooth muscle cell DNA after bisulphite sequencing of candidate genes (total n = 24 AAAs and 20 controls—Additional file 1: Table S2)

From: SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells

Gene, chromosome and RefSeq ID

RefSeq ID coordinate

Overall mean meth %

Overall mean meth %

Overall meth difference

P value

Q value

Age-adjusted

(CpG site)

± SD (AAA n = 24)

± SD (controls n = 20)

(% ± SE)

odds ratio

ERG

5389

19.00 (3.48)

14.83 (4.42)

4.17 (1.23)

0.0019

0.0037

NS

Chr: 21

5393

19.43 (3.72)

14.83 (3.618)

4.60 (1.16)

0.0004

0.0010

NS

NG_029732.1

5400

21.26 (5.76)

16.50 (10.57)

4.76 (2.58)

0.0002

0.0010

6.70

5402

20.43 (5.45)

14.83 (3.50)

5.60 (1.48)

0.0001

0.0009

NS

5405

19.96 (4.15)

14.89 (3.43)

5.07 (1.21)

0.0001

0.0008

6.18

5408

20.13 (4.20)

14.89 (3.51)

5.24 (1.23)

0.0001

0.0008

6.19

5429

24.13 (5.26)

18.56 ((3.22)

5.58 (1.41)

0.0003

0.0010

NS

5440

24.65 (4.49)

19.50 (3.40)

5.15 (1.28)

0.0001

0.0008

NS

5442

24.57 (5.12)

19.28 (3.25)

5.29 (1.38)

0.0002

0.0009

NS

5458

27.22 (4.88)

22.22 (3.15)

5.00 (1.33)

0.0003

0.0010

NS

5468

28.35 (6.01)

22.67 (3.16)

5.68 (1.56)

0.0015

0.0032

NS

5474

29.39 (5.55)

24.39 (3.48)

5.00 (1.50)

0.0012

0.0027

NS

5507

30.83 (5.57)

25.33 (3.09)

5.49 (1.46)

0.0004

0.0010

NS

IL6R Chr: 1

3570

93.17 (5.62)

76.70 (23.02)

16.47 (4.85)

0.0113

0.0743

3.11

NG_012087.1

3676

84.92 (10.89)

73.00 (17.49)

11.92 (4.31)

0.0176

0.0773

NS

SERPINB9

2889674

51.00 (16.19)

64.47 (16.19)

−13.47 (4.97)

0.0063

0.0375

NS

Chr: 6

2889644

20.46 (20.29)

8.579 (10.64)

11.88 (5.14)

0.0098

0.0478

3.29

NC_000006.12

2889627

71.67 (18.37)

82.53 (14.94)

−10.86 (5.20)

0.0058

0.0375

NS

2889620

62.88 (19.54)

79.11 (15.15)

−16.23 (5.47)

0.0017

0.0273

NS

2889612

70.33 (19.08)

80.37 (17.96)

−10.04 (5.71)

0.0064

0.0375

NS

2889568

76.58 (19.21)

87.21 (11.26)

−10.63 (4.97)

0.0012

0.0273

0.33

2889564

78.67 16.34)

88.58 (10.65)

−9.91 (4.35)

0.0010

0.0273

NS

SMYD2

214280412

39.50 (14.74)

55.67 (16.24)

−16.17 (6.00)

0.0004

0.0200

NS

Chr: 1

214280441

32.91 (10.53)

44.80 (17.29)

−11.89 (4.87)

0.0014

0.0299

0.09

NC_000001.11

214280507

38.78 (12.67)

49.22 (7.93)

−10.44 (4.56)

0.0016

0.0299

0.06

214280600

37.04 (11.02)

45.30 (11.43)

−8.26 (4.22)

0.0014

0.0299

0.03

  1. NS not significant