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Table 2 Mean observed CpG site methylation in vascular smooth muscle cell DNA after bisulphite sequencing of candidate genes (total n = 24 AAAs and 20 controls—Additional file 1: Table S2)

From: SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells

Gene, chromosome and RefSeq ID RefSeq ID coordinate Overall mean meth % Overall mean meth % Overall meth difference P value Q value Age-adjusted
(CpG site) ± SD (AAA n = 24) ± SD (controls n = 20) (% ± SE) odds ratio
ERG 5389 19.00 (3.48) 14.83 (4.42) 4.17 (1.23) 0.0019 0.0037 NS
Chr: 21 5393 19.43 (3.72) 14.83 (3.618) 4.60 (1.16) 0.0004 0.0010 NS
NG_029732.1 5400 21.26 (5.76) 16.50 (10.57) 4.76 (2.58) 0.0002 0.0010 6.70
5402 20.43 (5.45) 14.83 (3.50) 5.60 (1.48) 0.0001 0.0009 NS
5405 19.96 (4.15) 14.89 (3.43) 5.07 (1.21) 0.0001 0.0008 6.18
5408 20.13 (4.20) 14.89 (3.51) 5.24 (1.23) 0.0001 0.0008 6.19
5429 24.13 (5.26) 18.56 ((3.22) 5.58 (1.41) 0.0003 0.0010 NS
5440 24.65 (4.49) 19.50 (3.40) 5.15 (1.28) 0.0001 0.0008 NS
5442 24.57 (5.12) 19.28 (3.25) 5.29 (1.38) 0.0002 0.0009 NS
5458 27.22 (4.88) 22.22 (3.15) 5.00 (1.33) 0.0003 0.0010 NS
5468 28.35 (6.01) 22.67 (3.16) 5.68 (1.56) 0.0015 0.0032 NS
5474 29.39 (5.55) 24.39 (3.48) 5.00 (1.50) 0.0012 0.0027 NS
5507 30.83 (5.57) 25.33 (3.09) 5.49 (1.46) 0.0004 0.0010 NS
IL6R Chr: 1 3570 93.17 (5.62) 76.70 (23.02) 16.47 (4.85) 0.0113 0.0743 3.11
NG_012087.1 3676 84.92 (10.89) 73.00 (17.49) 11.92 (4.31) 0.0176 0.0773 NS
SERPINB9 2889674 51.00 (16.19) 64.47 (16.19) −13.47 (4.97) 0.0063 0.0375 NS
Chr: 6 2889644 20.46 (20.29) 8.579 (10.64) 11.88 (5.14) 0.0098 0.0478 3.29
NC_000006.12 2889627 71.67 (18.37) 82.53 (14.94) −10.86 (5.20) 0.0058 0.0375 NS
2889620 62.88 (19.54) 79.11 (15.15) −16.23 (5.47) 0.0017 0.0273 NS
2889612 70.33 (19.08) 80.37 (17.96) −10.04 (5.71) 0.0064 0.0375 NS
2889568 76.58 (19.21) 87.21 (11.26) −10.63 (4.97) 0.0012 0.0273 0.33
2889564 78.67 16.34) 88.58 (10.65) −9.91 (4.35) 0.0010 0.0273 NS
SMYD2 214280412 39.50 (14.74) 55.67 (16.24) −16.17 (6.00) 0.0004 0.0200 NS
Chr: 1 214280441 32.91 (10.53) 44.80 (17.29) −11.89 (4.87) 0.0014 0.0299 0.09
NC_000001.11 214280507 38.78 (12.67) 49.22 (7.93) −10.44 (4.56) 0.0016 0.0299 0.06
214280600 37.04 (11.02) 45.30 (11.43) −8.26 (4.22) 0.0014 0.0299 0.03
  1. NS not significant