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Table 5 Gene ontology (GO) analysis for cerebral palsy-associated DMRs. (DM: differentially methylated; FDR: false discovery rate)

From: Epigenome-wide analysis in newborn blood spots from monozygotic twins discordant for cerebral palsy reveals consistent regional differences in DNA methylation

GO ID

GO term

Ontology

No. of genes

DM genes

Unadjusted p value

FDR

GO:0002705

Positive regulation of leukocyte mediated immunity

BP

80

5

4.57E-10

9.60E-06

GO:0002703

Regulation of leukocyte mediated immunity

BP

139

5

7.48E-09

5.26E-05

GO:0002699

Positive regulation of immune effector process

BP

142

5

7.52E-09

5.26E-05

GO:0050715

Positive regulation of cytokine secretion

BP

91

4

8.69E-08

4.56E-04

GO:0002443

Leukocyte mediated immunity

BP

258

5

1.42E-07

5.95E-04

GO:0002697

Regulation of immune effector process

BP

291

5

4.04E-07

1.09E-03

GO:0042742

Defence response to bacterium

BP

204

4

4.13E-07

1.09E-03

GO:0050778

Positive regulation of immune response

BP

571

6

4.17E-07

1.09E-03

GO:0050707

Regulation of cytokine secretion

BP

135

4

5.96E-07

1.39E-03

GO:0050663

Cytokine secretion

BP

154

4

9.84E-07

2.06E-03

GO:0001819

Positive regulation of cytokine production

BP

360

5

1.32E-06

2.52E-03

GO:0002876

Positive regulation of chronic inflammatory Response to antigenic stimulus

BP

2

2

1.61E-06

2.81E-03

GO:0050776

Regulation of immune response

BP

769

6

1.82E-06

2.82E-03

GO:0002682

Regulation of immune system process

BP

1191

7

1.88E-06

2.82E-03

GO:0002874

Regulation of chronic inflammatory response to antigenic stimulus

BP

3

2

2.15E-06

3.00E-03

GO:0050830

Defence response to Gram-positive bacterium

BP

68

3

2.45E-06

3.22E-03

GO:0002925

Positive regulation of humoral immune response mediated by circulating immunoglobulin

BP

4

2

2.82E-06

3.48E-03

GO:0002678

Positive regulation of chronic inflammatory response

BP

4

2

3.23E-06

3.76E-03

GO:0002718

Regulation of cytokine production involved in immune response

BP

52

3

3.84E-06

4.24E-03

GO:0002684

Positive regulation of immune system process

BP

820

6

4.24E-06

4.44E-03