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Table 2 The top-ranked DMPs (ranked on unadjusted p value) in cerebral palsy discordant twins

From: Epigenome-wide analysis in newborn blood spots from monozygotic twins discordant for cerebral palsy reveals consistent regional differences in DNA methylation

Probe ID Rank Chromosome position Gene Location P value Methylation difference (%)
cg00376816 1 chr19: 39332571 HNRNPL   4.57E-06 11.64
cg25011252 2 chr8: 61777859 CHD7   6.33E-06 7.64
cg04242728 3 chr16: 2536153 TBC1D24   1.46E-05 − 8.20
cg03907855 4 chr8: 1106363 Island 1.52E-05 − 3.20
cg05707458 5 chr1: 205424829 Island 1.93E-05 2.39
cg18369327 6 chr5: 109220986 LOC100289673   2.07E-05 − 2.54
cg18768238 7 chr10: 49892829 WDFY4   2.52E-05 − 8.58
cg14163311 8 chr1: 206730397 RASSF5   3.21E-05 8.20
cg16602500 9 chr1: 52889575 ZCCHC11   3.64E-05 6.25
cg06419846 10 chr11: 66083572 CD248   3.65E-05 5.95
cg03929569 11 chr13: 30688864 Island 4.35E-05 0.60
cg14414943 12 chr1: 111770718 CHI3L2   4.65E-05 6.21
cg19607845 13 chr6: 52930050 FBXO9   4.79E-05 − 9.61
cg19942731 14 chr22: 45609421 C22orf9   5.11E-05 − 10.38
cg14073571 15 chr7: 158823178 VIPR2   5.14E-05 − 7.59
cg03106245 16 chr11: 47399788 SPI1   5.33E-05 − 11.45
cg08936645 17 chr4: 37910273 TBC1D1   5.36E-05 − 7.84
cg02806715 18 chr6: 32920567 HLA-DMA   5.69E-05 − 6.58
cg17512380 19 chr10: 18971598 OpenSea 5.81E-05 5.67
ch.10.89216809R 20 chr10: 89226829 OpenSea 6.52E-05 − 3.85
cg15613292 21 chr2: 232478359 Shore 6.89E-05 2.62
cg00263248 22 chr14: 98444151 C14orf64   6.94E-05 6.40
cg19540797 23 chr2: 3605489 RNASEH1   7.30E-05 2.27
cg08360638 24 chr13: 20781097 OpenSea 7.52E-05 7.09
cg07728874 25 chr11: 118213272 CD3D   7.93E-05 9.14
cg11348257 26 chr1: 76556226 ST6GALNAC3   8.03E-05 − 12.35
cg07011093 27 chr3: 123987726 KALRN   8.38E-05 − 5.03
cg09335613 28 chr6: 71998106 OGFRL1   8.85E-05 − 6.68
cg22230912 29 chr3: 16331335 OXNAD1   8.90E-05 11.86
cg13505608 30 chr9: 140128562 SLC34A3   9.22E-05 2.53
cg04975778 31 chr2: 62732758 TMEM17   9.26E-05 2.31
cg12306086 32 chr4: 106117747 TET2   9.52E-05 − 10.22
  1. Methylation difference (%) was calculated as the mean of the DNA methylation levels of the CP twin minus the unaffected twin (Δβ)