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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Peripheral blood epi-signature of Claes-Jensen syndrome enables sensitive and specific identification of patients and healthy carriers with pathogenic mutations in KDM5C

Fig. 2

Clustering of the patients, carriers, and controls using the epi-signature: a unsupervised hierarchical clustering of patients, carriers, and normal controls shows two distinct clusters for patients (blue bar), and controls (red bar), and an intermediate cluster for the carriers (green bar). The rows represent the individual probes, and the columns represent the individual samples. Dark blue represents hypermethylation, and light blue represents hypomethylation in patients relative to the controls. b The first two components of the principal component analysis of patients (blue), carriers (green), and controls (red), based on the methylation status of the probes in the epi-signature, show a complete separation of patients from controls, while the carriers are placed in between the two

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Clinical Epigenetics

ISSN: 1868-7083

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