Table 4 Results from the ICE FALCON analyses
From: Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study
CpGs | Coefficient | Model 1 | Model 2 | Model 3 | Change | ||||
|---|---|---|---|---|---|---|---|---|---|
Estimate (SE) | P | Estimate (SE) | P | Estimate (SE) | P | Estimate (SE) | P | ||
CpGs reported by Joehanes et al. | |||||||||
 Smoking as the predictor | β self | 74.61 (9.87) | 4.0E-14 | – | – | 75.45 (9.29) | 4.4E-16 | 0.84 (3.60) | 4.1E-01 |
β co-twin | – | – | − 30.84 (13.69) | 2.4E-02 | 2.50 (9.57) | 7.9E-01 | − 33.34 (11.60) | 2.1E-03 | |
 Methylation score as the predictor | β self | 4.07 (0.70) | 7.5E-09 | – | – | 4.45 (0.81) | 3.6E-08 | 0.39 (0.47) | 2.1E-01 |
β co-twin | – | – | 0.41 (0.72) | 5.7E-01 | − 1.00 (0.82) | 2.2E-01 | − 1.42 (1.15) | 1.1E-01 | |
CpGs identified from our study | |||||||||
 Smoking as the predictor | β self | 27.70 (3.65) | 3.4E-14 | – | – | 26.89 (3.79) | 1.2E-12 | − 0.81 (0.89) | 1.8E-01 |
β co-twin | – | – | − 12.36 (3.86) | 1.4E-03 | − 3.45 (2.58) | 1.8E-01 | − 8.90 (5.52) | 5.3E-02 | |
 Methylation score as the predictor | β self | 10.24 (2.19) | 1.3E-08 | – | – | 11.14 (2.47) | 6.7E-06 | 0.90 (1.27) | 2.4E-01 |
β co-twin | – | – | − 4.48 (2.65) | 9.2E-02 | − 3.86 (2.66) | 1.5E-01 | 0.61 (3.77) | 4.4E-01 | |