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Table 4 Results from the ICE FALCON analyses

From: Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study

CpGs Coefficient Model 1 Model 2 Model 3 Change
Estimate (SE) P Estimate (SE) P Estimate (SE) P Estimate (SE) P
CpGs reported by Joehanes et al.
 Smoking as the predictor β self 74.61 (9.87) 4.0E-14 75.45 (9.29) 4.4E-16 0.84 (3.60) 4.1E-01
β co-twin − 30.84 (13.69) 2.4E-02 2.50 (9.57) 7.9E-01 − 33.34 (11.60) 2.1E-03
 Methylation score as the predictor β self 4.07 (0.70) 7.5E-09 4.45 (0.81) 3.6E-08 0.39 (0.47) 2.1E-01
β co-twin 0.41 (0.72) 5.7E-01 − 1.00 (0.82) 2.2E-01 − 1.42 (1.15) 1.1E-01
CpGs identified from our study
 Smoking as the predictor β self 27.70 (3.65) 3.4E-14 26.89 (3.79) 1.2E-12 − 0.81 (0.89) 1.8E-01
β co-twin − 12.36 (3.86) 1.4E-03 − 3.45 (2.58) 1.8E-01 − 8.90 (5.52) 5.3E-02
 Methylation score as the predictor β self 10.24 (2.19) 1.3E-08 11.14 (2.47) 6.7E-06 0.90 (1.27) 2.4E-01
β co-twin − 4.48 (2.65) 9.2E-02 − 3.86 (2.66) 1.5E-01 0.61 (3.77) 4.4E-01
  1. Regression coefficients from the analyses in which the methylation score as the predictor were reported as being multiplied by 100, as well as for standard errors