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Table 3 Associations of methylation at the 39 identified CpGs with smoking status, pack-years and years since quitting from the between- and within-sibship analyses

From: Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study

CpG Smoking status Pack-years Years since quitting
Between-sibship coefficient (SE) Within-sibship coefficient (SE) P* Between-sibship coefficient (SE) Within-sibship coefficient (SE) P* Between-sibship coefficient (SE) Within-sibship coefficient (SE) P*
cg05575921 − 0.87 (0.12) − 0.93 (0.08) 0.65 − 14.53 (4.65) − 6.58 (3.76) 0.18 1.53 (0.57) 1.76 (0.52) 0.77
cg05951221 − 0.59 (0.10) − 0.47 (0.07) 0.32 − 13.28 (4.08) − 6.74 (2.87) 0.19 1.75 (0.43) 1.56 (0.41) 0.75
cg01940273 − 0.60 (0.10) − 0.47 (0.06) 0.26 − 8.04 (3.30) − 6.32 (2.88) 0.69 1.36 (0.35) 1.77 (0.41) 0.44
cg03636183 − 0.56 (0.09) − 0.41 (0.06) 0.18 − 2.63 (4.55) − 2.93 (2.90) 0.96 0.57 (0.50) 1.18 (0.41) 0.34
cg06126421 − 0.34 (0.14) − 0.48 (0.08) 0.37 − 13.31 (6.51) − 5.02 (3.69) 0.27 1.59 (0.68) 1.62 (0.52) 0.98
cg26703534 − 0.21 (0.06) − 0.30 (0.04) 0.17 − 2.34 (2.07) 2.74 (1.62) 0.05 − 0.33 (0.28) − 0.41 (0.24) 0.84
cg21161138 − 0.36 (0.09) − 0.37 (0.06) 0.91 − 4.37 (4.08) − 3.20 (2.41) 0.81 0.46 (0.47) 0.91 (0.36) 0.45
cg11660018 − 0.26 (0.08) − 0.20 (0.04) 0.46 − 5.50 (2.48) 0.51 (2.11) 0.07 1.01 (0.28) 0.88 (0.29) 0.75
cg09935388 − 0.58 (0.14) − 0.53 (0.10) 0.77 − 2.29 (5.39) − 5.44 (4.01) 0.64 0.71 (0.68) 1.32 (0.59) 0.50
cg25648203 − 0.16 (0.08) − 0.31 (0.05) 0.10 − 6.26 (2.96) − 1.05 (2.12) 0.15 0.77 (0.36) 0.27 (0.30) 0.29
cg19859270 − 0.28 (0.08) − 0.22 (0.05) 0.51 − 4.06 (3.48) − 1.60 (2.63) 0.57 0.70 (0.34) 0.39 (0.38) 0.54
cg03329539 − 0.31 (0.08) − 0.28 (0.06) 0.79 − 4.34 (3.26) − 6.70 (2.45) 0.56 0.78 (0.35) 0.95 (0.35) 0.73
cg24859433 − 0.15 (0.07) − 0.24 (0.05) 0.25 − 3.51 (2.81) − 0.74 (2.12) 0.43 0.71 (0.30) 0.47 (0.32) 0.59
cg14753356 − 0.13 (0.07) − 0.16 (0.04) 0.73 − 0.21 (3.36) − 3.43 (1.78) 0.40 0.61 (0.34) 0.33 (0.27) 0.52
cg07339236 − 0.29 (0.11) − 0.32 (0.07) 0.83 − 1.48 (4.44) − 0.56 (3.24) 0.87 0.88 (0.48) 0.62 (0.48) 0.70
cg04885881 − 0.26 (0.08) − 0.24 (0.05) 0.80 − 0.68 (2.88) 0.24 (2.12) 0.80 0.45 (0.32) 0.26 (0.32) 0.67
cg23916896 − 0.40 (0.15) − 0.49 (0.10) 0.60 − 9.52 (5.34) 8.79 (4.31) 0.01 0.72 (0.62) − 0.13 (0.67) 0.35
cg14817490 − 0.18 (0.09) − 0.28 (0.05) 0.32 − 2.65 (3.72) − 2.45 (2.15) 0.96 0.30 (0.42) 0.55 (0.30) 0.63
cg11902777 − 0.40 (0.14) − 0.44 (0.09) 0.80 − 14.37 (4.30) − 2.35 (3.70) 0.03 1.22 (0.54) 0.70 (0.56) 0.50
cg21611682 − 0.15 (0.05) − 0.16 (0.03) 0.88 − 1.63 (1.75) − 1.82 (1.48) 0.93 0.34 (0.22) 0.42 (0.22) 0.80
cg01692968 − 0.11 (0.09) − 0.16 (0.06) 0.61 − 4.60 (3.02) 0.19 (2.32) 0.21 0.76 (0.39) 0.51 (0.34) 0.63
cg08709672 − 0.07 (0.06) − 0.17 (0.03) 0.12 1.06 (2.28) − 1.11 (1.30) 0.41 0.08 (0.26) 0.56 (0.19) 0.13
cg07826859 − 0.16 (0.06) − 0.20 (0.04) 0.52 − 2.02 (2.59) − 1.05 (1.69) 0.75 0.09 (0.26) 0.41 (0.24) 0.37
cg25189904 − 0.46 (0.11) − 0.29 (0.09) 0.21 − 11.29 (4.40) − 0.82 (4.21) 0.09 0.20 (0.57) 1.09 (0.61) 0.29
cg17287155 − 0.23 (0.08) − 0.19 (0.05) 0.65 − 1.78 (2.87) 2.63 (2.03) 0.21 0.49 (0.3) − 0.16 (0.32) 0.14
cg06226150 − 0.19 (0.05) − 0.13 (0.04) 0.36 − 2.55 (2.48) − 2.00 (1.44) 0.85 − 0.14 (0.26) 0.36 (0.22) 0.14
cg23161492 − 0.28 (0.11) − 0.24 (0.06) 0.74 − 8.68 (4.48) − 4.66 (2.44) 0.43 0.55 (0.51) 0.81 (0.37) 0.68
cg09022230 − 0.12 (0.08) − 0.25 (0.05) 0.17 5.91 (2.41) − 3.44 (1.92) 0.00 − 0.13 (0.34) 0.73 (0.29) 0.06
cg19572487 − 0.14 (0.07) − 0.20 (0.06) 0.54 − 8.14 (3.10) − 1.86 (2.16) 0.10 0.75 (0.37) 0.69 (0.33) 0.91
cg03991871 − 0.39 (0.16) − 0.38 (0.08) 0.98 − 5.86 (5.57) − 0.98 (4.13) 0.48 0.10 (0.63) 0.29 (0.63) 0.83
cg14580211 − 0.15 (0.09) − 0.24 (0.05) 0.33 − 3.40 (3.54) 0.79 (2.41) 0.33 1.00 (0.37) 0.46 (0.33) 0.27
cg15187398 − 0.18 (0.08) − 0.18 (0.05) 0.96 − 2.81 (3.07) 1.55 (2.24) 0.25 0.23 (0.39) 0.15 (0.35) 0.87
cg10750182 − 0.08 (0.04) − 0.11 (0.03) 0.53 − 0.79 (1.75) 0.47 (1.18) 0.55 0.07 (0.19) 0.23 (0.17) 0.55
cg25949550 − 0.13 (0.07) − 0.20 (0.05) 0.39 − 1.05 (2.47) 0.12 (2.36) 0.73 0.44 (0.30) 0.81 (0.34) 0.41
cg05284742 − 0.16 (0.06) − 0.14 (0.05) 0.86 3.53 (2.18) − 1.18 (1.94) 0.11 0.20 (0.30) 0.30 (0.28) 0.81
cg23931381 − 0.08 (0.08) − 0.20 (0.06) 0.25 1.09 (3.58) 1.77 (2.65) 0.88 − 0.16 (0.43) 0.46 (0.37) 0.27
cg26271591 − 0.16 (0.10) − 0.32 (0.07) 0.19 − 4.11 (4.56) 0.95 (3.10) 0.36 0.41 (0.46) 0.52 (0.45) 0.87
cg03646329 − 0.29 (0.13) − 0.27 (0.08) 0.90 − 10.07 (5.29) − 1.22 (3.22) 0.15 0.80 (0.64) 0.66 (0.46) 0.86
cg21733098 − 0.37 (0.16) − 0.31 (0.09) 0.76 − 4.20 (6.47) 2.68 (4.37) 0.38 0.19 (0.70) − 0.14 (0.67) 0.74
  1. Regression coefficients from the analyses for pack-years and years since quitting were reported as being multiplied by 100, as well as for standard errors
  2. *P-value from comparing the between-sibship coefficient with the within-sibship coefficient