Table 3 Associations of methylation at the 39 identified CpGs with smoking status, pack-years and years since quitting from the between- and within-sibship analyses
From: Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study
CpG | Smoking status | Pack-years | Years since quitting | ||||||
|---|---|---|---|---|---|---|---|---|---|
Between-sibship coefficient (SE) | Within-sibship coefficient (SE) | P* | Between-sibship coefficient (SE) | Within-sibship coefficient (SE) | P* | Between-sibship coefficient (SE) | Within-sibship coefficient (SE) | P* | |
cg05575921 | − 0.87 (0.12) | − 0.93 (0.08) | 0.65 | − 14.53 (4.65) | − 6.58 (3.76) | 0.18 | 1.53 (0.57) | 1.76 (0.52) | 0.77 |
cg05951221 | − 0.59 (0.10) | − 0.47 (0.07) | 0.32 | − 13.28 (4.08) | − 6.74 (2.87) | 0.19 | 1.75 (0.43) | 1.56 (0.41) | 0.75 |
cg01940273 | − 0.60 (0.10) | − 0.47 (0.06) | 0.26 | − 8.04 (3.30) | − 6.32 (2.88) | 0.69 | 1.36 (0.35) | 1.77 (0.41) | 0.44 |
cg03636183 | − 0.56 (0.09) | − 0.41 (0.06) | 0.18 | − 2.63 (4.55) | − 2.93 (2.90) | 0.96 | 0.57 (0.50) | 1.18 (0.41) | 0.34 |
cg06126421 | − 0.34 (0.14) | − 0.48 (0.08) | 0.37 | − 13.31 (6.51) | − 5.02 (3.69) | 0.27 | 1.59 (0.68) | 1.62 (0.52) | 0.98 |
cg26703534 | − 0.21 (0.06) | − 0.30 (0.04) | 0.17 | − 2.34 (2.07) | 2.74 (1.62) | 0.05 | − 0.33 (0.28) | − 0.41 (0.24) | 0.84 |
cg21161138 | − 0.36 (0.09) | − 0.37 (0.06) | 0.91 | − 4.37 (4.08) | − 3.20 (2.41) | 0.81 | 0.46 (0.47) | 0.91 (0.36) | 0.45 |
cg11660018 | − 0.26 (0.08) | − 0.20 (0.04) | 0.46 | − 5.50 (2.48) | 0.51 (2.11) | 0.07 | 1.01 (0.28) | 0.88 (0.29) | 0.75 |
cg09935388 | − 0.58 (0.14) | − 0.53 (0.10) | 0.77 | − 2.29 (5.39) | − 5.44 (4.01) | 0.64 | 0.71 (0.68) | 1.32 (0.59) | 0.50 |
cg25648203 | − 0.16 (0.08) | − 0.31 (0.05) | 0.10 | − 6.26 (2.96) | − 1.05 (2.12) | 0.15 | 0.77 (0.36) | 0.27 (0.30) | 0.29 |
cg19859270 | − 0.28 (0.08) | − 0.22 (0.05) | 0.51 | − 4.06 (3.48) | − 1.60 (2.63) | 0.57 | 0.70 (0.34) | 0.39 (0.38) | 0.54 |
cg03329539 | − 0.31 (0.08) | − 0.28 (0.06) | 0.79 | − 4.34 (3.26) | − 6.70 (2.45) | 0.56 | 0.78 (0.35) | 0.95 (0.35) | 0.73 |
cg24859433 | − 0.15 (0.07) | − 0.24 (0.05) | 0.25 | − 3.51 (2.81) | − 0.74 (2.12) | 0.43 | 0.71 (0.30) | 0.47 (0.32) | 0.59 |
cg14753356 | − 0.13 (0.07) | − 0.16 (0.04) | 0.73 | − 0.21 (3.36) | − 3.43 (1.78) | 0.40 | 0.61 (0.34) | 0.33 (0.27) | 0.52 |
cg07339236 | − 0.29 (0.11) | − 0.32 (0.07) | 0.83 | − 1.48 (4.44) | − 0.56 (3.24) | 0.87 | 0.88 (0.48) | 0.62 (0.48) | 0.70 |
cg04885881 | − 0.26 (0.08) | − 0.24 (0.05) | 0.80 | − 0.68 (2.88) | 0.24 (2.12) | 0.80 | 0.45 (0.32) | 0.26 (0.32) | 0.67 |
cg23916896 | − 0.40 (0.15) | − 0.49 (0.10) | 0.60 | − 9.52 (5.34) | 8.79 (4.31) | 0.01 | 0.72 (0.62) | − 0.13 (0.67) | 0.35 |
cg14817490 | − 0.18 (0.09) | − 0.28 (0.05) | 0.32 | − 2.65 (3.72) | − 2.45 (2.15) | 0.96 | 0.30 (0.42) | 0.55 (0.30) | 0.63 |
cg11902777 | − 0.40 (0.14) | − 0.44 (0.09) | 0.80 | − 14.37 (4.30) | − 2.35 (3.70) | 0.03 | 1.22 (0.54) | 0.70 (0.56) | 0.50 |
cg21611682 | − 0.15 (0.05) | − 0.16 (0.03) | 0.88 | − 1.63 (1.75) | − 1.82 (1.48) | 0.93 | 0.34 (0.22) | 0.42 (0.22) | 0.80 |
cg01692968 | − 0.11 (0.09) | − 0.16 (0.06) | 0.61 | − 4.60 (3.02) | 0.19 (2.32) | 0.21 | 0.76 (0.39) | 0.51 (0.34) | 0.63 |
cg08709672 | − 0.07 (0.06) | − 0.17 (0.03) | 0.12 | 1.06 (2.28) | − 1.11 (1.30) | 0.41 | 0.08 (0.26) | 0.56 (0.19) | 0.13 |
cg07826859 | − 0.16 (0.06) | − 0.20 (0.04) | 0.52 | − 2.02 (2.59) | − 1.05 (1.69) | 0.75 | 0.09 (0.26) | 0.41 (0.24) | 0.37 |
cg25189904 | − 0.46 (0.11) | − 0.29 (0.09) | 0.21 | − 11.29 (4.40) | − 0.82 (4.21) | 0.09 | 0.20 (0.57) | 1.09 (0.61) | 0.29 |
cg17287155 | − 0.23 (0.08) | − 0.19 (0.05) | 0.65 | − 1.78 (2.87) | 2.63 (2.03) | 0.21 | 0.49 (0.3) | − 0.16 (0.32) | 0.14 |
cg06226150 | − 0.19 (0.05) | − 0.13 (0.04) | 0.36 | − 2.55 (2.48) | − 2.00 (1.44) | 0.85 | − 0.14 (0.26) | 0.36 (0.22) | 0.14 |
cg23161492 | − 0.28 (0.11) | − 0.24 (0.06) | 0.74 | − 8.68 (4.48) | − 4.66 (2.44) | 0.43 | 0.55 (0.51) | 0.81 (0.37) | 0.68 |
cg09022230 | − 0.12 (0.08) | − 0.25 (0.05) | 0.17 | 5.91 (2.41) | − 3.44 (1.92) | 0.00 | − 0.13 (0.34) | 0.73 (0.29) | 0.06 |
cg19572487 | − 0.14 (0.07) | − 0.20 (0.06) | 0.54 | − 8.14 (3.10) | − 1.86 (2.16) | 0.10 | 0.75 (0.37) | 0.69 (0.33) | 0.91 |
cg03991871 | − 0.39 (0.16) | − 0.38 (0.08) | 0.98 | − 5.86 (5.57) | − 0.98 (4.13) | 0.48 | 0.10 (0.63) | 0.29 (0.63) | 0.83 |
cg14580211 | − 0.15 (0.09) | − 0.24 (0.05) | 0.33 | − 3.40 (3.54) | 0.79 (2.41) | 0.33 | 1.00 (0.37) | 0.46 (0.33) | 0.27 |
cg15187398 | − 0.18 (0.08) | − 0.18 (0.05) | 0.96 | − 2.81 (3.07) | 1.55 (2.24) | 0.25 | 0.23 (0.39) | 0.15 (0.35) | 0.87 |
cg10750182 | − 0.08 (0.04) | − 0.11 (0.03) | 0.53 | − 0.79 (1.75) | 0.47 (1.18) | 0.55 | 0.07 (0.19) | 0.23 (0.17) | 0.55 |
cg25949550 | − 0.13 (0.07) | − 0.20 (0.05) | 0.39 | − 1.05 (2.47) | 0.12 (2.36) | 0.73 | 0.44 (0.30) | 0.81 (0.34) | 0.41 |
cg05284742 | − 0.16 (0.06) | − 0.14 (0.05) | 0.86 | 3.53 (2.18) | − 1.18 (1.94) | 0.11 | 0.20 (0.30) | 0.30 (0.28) | 0.81 |
cg23931381 | − 0.08 (0.08) | − 0.20 (0.06) | 0.25 | 1.09 (3.58) | 1.77 (2.65) | 0.88 | − 0.16 (0.43) | 0.46 (0.37) | 0.27 |
cg26271591 | − 0.16 (0.10) | − 0.32 (0.07) | 0.19 | − 4.11 (4.56) | 0.95 (3.10) | 0.36 | 0.41 (0.46) | 0.52 (0.45) | 0.87 |
cg03646329 | − 0.29 (0.13) | − 0.27 (0.08) | 0.90 | − 10.07 (5.29) | − 1.22 (3.22) | 0.15 | 0.80 (0.64) | 0.66 (0.46) | 0.86 |
cg21733098 | − 0.37 (0.16) | − 0.31 (0.09) | 0.76 | − 4.20 (6.47) | 2.68 (4.37) | 0.38 | 0.19 (0.70) | − 0.14 (0.67) | 0.74 |