Table 2 Associations of methylation at the 39 identified CpGs with pack-years and years since quitting
From: Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study
CpG | Pack-years | Years since quitting | ||||
|---|---|---|---|---|---|---|
Estimate (SE) | P value | FDR | Estimate (SE) | P value | FDR | |
cg05575921 | − 10.68 (2.18) | 1.11E-06 | 1.44E-05 | 1.63 (0.30) | 1.11E-35 | 7.35E-08 |
cg05951221 | − 10.32 (1.70) | 3.04E-09 | 1.19E-07 | 1.66 (0.25) | 2.08E-23 | 1.55E-10 |
cg01940273 | − 8.99 (1.58) | 1.93E-08 | 3.76E-07 | 1.47 (0.23) | 1.41E-20 | 1.15E-09 |
cg03636183 | − 4.65 (1.70) | 5.35E-03 | 1.90E-02 | 0.98 (0.24) | 2.94E-17 | 5.87E-05 |
cg06126421 | − 5.92 (2.20) | 6.15E-03 | 2.00E-02 | 1.31 (0.32) | 1.00E-12 | 3.36E-05 |
cg26703534 | 0.28 (0.98) | 8.02E-01 | 8.02E-01 | − 0.3 (0.15) | 3.04E-11 | 3.44E-02 |
cg21161138 | − 4.30 (1.62) | 6.89E-03 | 2.07E-02 | 0.65 (0.24) | 7.11E-10 | 5.32E-03 |
cg11660018 | − 3.74 (1.13) | 7.82E-04 | 4.36E-03 | 0.83 (0.17) | 4.42E-07 | 5.86E-07 |
cg09935388 | − 6.87 (2.40) | 3.06E-03 | 1.19E-02 | 1.10 (0.35) | 2.70E-06 | 1.63E-03 |
cg25648203 | − 2.25 (1.28) | 7.19E-02 | 1.27E-01 | 0.37 (0.19) | 6.71E-06 | 4.18E-02 |
cg19859270 | − 2.69 (1.38) | 4.65E-02 | 9.55E-02 | 0.58 (0.21) | 1.04E-05 | 4.41E-03 |
cg03329539 | − 6.27 (1.35) | 3.59E-06 | 3.50E-05 | 0.83 (0.21) | 1.73E-05 | 5.13E-05 |
cg24859433 | − 1.45 (1.21) | 2.04E-01 | 2.65E-01 | 0.41 (0.18) | 1.85E-05 | 1.78E-02 |
cg14753356 | − 2.64 (1.12) | 1.63E-02 | 3.74E-02 | 0.38 (0.18) | 1.85E-05 | 2.28E-02 |
cg07339236 | − 2.71 (1.93) | 1.51E-01 | 2.26E-01 | 0.89 (0.30) | 1.01E-04 | 2.21E-03 |
cg04885881 | − 2.16 (1.29) | 7.80E-02 | 1.32E-01 | 0.28 (0.20) | 1.15E-04 | 1.18E-01 |
cg23916896 | − 4.32 (2.41) | 6.61E-02 | 1.23E-01 | 0.47 (0.37) | 2.43E-04 | 1.84E-01 |
cg14817490 | − 3.31 (1.35) | 1.26E-02 | 3.28E-02 | 0.35 (0.21) | 3.14E-04 | 1.02E-01 |
cg11902777 | − 7.19 (2.15) | 6.99E-04 | 4.36E-03 | 0.65 (0.32) | 8.55E-04 | 4.06E-02 |
cg21611682 | − 2.04 (0.80) | 9.75E-03 | 2.72E-02 | 0.27 (0.12) | 8.55E-04 | 2.25E-02 |
cg01692968 | − 2.37 (1.42) | 8.83E-02 | 1.43E-01 | 0.72 (0.21) | 1.09E-03 | 5.77E-04 |
cg08709672 | − 1.05 (0.80) | 1.75E-01 | 2.43E-01 | 0.29 (0.12) | 1.22E-03 | 1.91E-02 |
cg07826859 | − 1.75 (0.97) | 6.23E-02 | 1.21E-01 | 0.17 (0.15) | 2.04E-03 | 2.48E-01 |
cg25189904 | − 7.02 (2.23) | 1.38E-03 | 6.72E-03 | 0.74 (0.34) | 2.33E-03 | 2.45E-02 |
cg17287155 | − 1.67 (1.27) | 1.74E-01 | 2.43E-01 | 0.31 (0.18) | 3.61E-03 | 7.50E-02 |
cg06226150 | − 1.37 (0.88) | 1.12E-01 | 1.74E-01 | 0.21 (0.14) | 4.51E-03 | 1.24E-01 |
cg23161492 | − 5.41 (1.57) | 5.18E-04 | 4.04E-03 | 0.68 (0.24) | 9.43E-03 | 3.95E-03 |
cg09022230 | 0.73 (1.23) | 5.42E-01 | 6.21E-01 | 0.15 (0.19) | 9.65E-03 | 4.52E-01 |
cg19572487 | − 4.19 (1.44) | 2.96E-03 | 1.19E-02 | 0.60 (0.20) | 1.07E-02 | 2.64E-03 |
cg03991871 | − 5.59 (2.37) | 1.63E-02 | 3.74E-02 | 0.40 (0.36) | 1.25E-02 | 2.48E-01 |
cg14580211 | − 0.43 (1.40) | 7.46E-01 | 7.86E-01 | 0.43 (0.21) | 1.48E-02 | 3.25E-02 |
cg15187398 | − 1.28 (1.31) | 3.10E-01 | 3.90E-01 | 0.15 (0.20) | 1.60E-02 | 4.27E-01 |
cg10750182 | − 0.64 (0.67) | 3.20E-01 | 3.90E-01 | 0.15 (0.10) | 2.53E-02 | 1.05E-01 |
cg25949550 | − 2.80 (1.25) | 2.24E-02 | 4.86E-02 | 0.59 (0.20) | 3.19E-02 | 2.17E-03 |
cg05284742 | − 0.49 (1.13) | 6.58E-01 | 7.13E-01 | 0.21 (0.16) | 3.24E-02 | 1.81E-01 |
cg23931381 | 0.71 (1.50) | 6.03E-01 | 6.72E-01 | 0.20 (0.23) | 3.40E-02 | 4.26E-01 |
cg26271591 | − 0.44 (1.74) | 7.87E-01 | 8.02E-01 | 0.34 (0.26) | 4.72E-02 | 1.77E-01 |
cg03646329 | − 2.47 (1.98) | 1.99E-01 | 2.65E-01 | 0.63 (0.30) | 4.72E-02 | 3.08E-02 |
cg21733098 | − 1.78 (2.49) | 4.55E-01 | 5.38E-01 | − 0.03 (0.38) | 4.72E-02 | 9.23E-01 |