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Table 2 Associations of methylation at the 39 identified CpGs with pack-years and years since quitting

From: Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study

CpG Pack-years Years since quitting
Estimate (SE) P value FDR Estimate (SE) P value FDR
cg05575921 − 10.68 (2.18) 1.11E-06 1.44E-05 1.63 (0.30) 1.11E-35 7.35E-08
cg05951221 − 10.32 (1.70) 3.04E-09 1.19E-07 1.66 (0.25) 2.08E-23 1.55E-10
cg01940273 − 8.99 (1.58) 1.93E-08 3.76E-07 1.47 (0.23) 1.41E-20 1.15E-09
cg03636183 − 4.65 (1.70) 5.35E-03 1.90E-02 0.98 (0.24) 2.94E-17 5.87E-05
cg06126421 − 5.92 (2.20) 6.15E-03 2.00E-02 1.31 (0.32) 1.00E-12 3.36E-05
cg26703534 0.28 (0.98) 8.02E-01 8.02E-01 − 0.3 (0.15) 3.04E-11 3.44E-02
cg21161138 − 4.30 (1.62) 6.89E-03 2.07E-02 0.65 (0.24) 7.11E-10 5.32E-03
cg11660018 − 3.74 (1.13) 7.82E-04 4.36E-03 0.83 (0.17) 4.42E-07 5.86E-07
cg09935388 − 6.87 (2.40) 3.06E-03 1.19E-02 1.10 (0.35) 2.70E-06 1.63E-03
cg25648203 − 2.25 (1.28) 7.19E-02 1.27E-01 0.37 (0.19) 6.71E-06 4.18E-02
cg19859270 − 2.69 (1.38) 4.65E-02 9.55E-02 0.58 (0.21) 1.04E-05 4.41E-03
cg03329539 − 6.27 (1.35) 3.59E-06 3.50E-05 0.83 (0.21) 1.73E-05 5.13E-05
cg24859433 − 1.45 (1.21) 2.04E-01 2.65E-01 0.41 (0.18) 1.85E-05 1.78E-02
cg14753356 − 2.64 (1.12) 1.63E-02 3.74E-02 0.38 (0.18) 1.85E-05 2.28E-02
cg07339236 − 2.71 (1.93) 1.51E-01 2.26E-01 0.89 (0.30) 1.01E-04 2.21E-03
cg04885881 − 2.16 (1.29) 7.80E-02 1.32E-01 0.28 (0.20) 1.15E-04 1.18E-01
cg23916896 − 4.32 (2.41) 6.61E-02 1.23E-01 0.47 (0.37) 2.43E-04 1.84E-01
cg14817490 − 3.31 (1.35) 1.26E-02 3.28E-02 0.35 (0.21) 3.14E-04 1.02E-01
cg11902777 − 7.19 (2.15) 6.99E-04 4.36E-03 0.65 (0.32) 8.55E-04 4.06E-02
cg21611682 − 2.04 (0.80) 9.75E-03 2.72E-02 0.27 (0.12) 8.55E-04 2.25E-02
cg01692968 − 2.37 (1.42) 8.83E-02 1.43E-01 0.72 (0.21) 1.09E-03 5.77E-04
cg08709672 − 1.05 (0.80) 1.75E-01 2.43E-01 0.29 (0.12) 1.22E-03 1.91E-02
cg07826859 − 1.75 (0.97) 6.23E-02 1.21E-01 0.17 (0.15) 2.04E-03 2.48E-01
cg25189904 − 7.02 (2.23) 1.38E-03 6.72E-03 0.74 (0.34) 2.33E-03 2.45E-02
cg17287155 − 1.67 (1.27) 1.74E-01 2.43E-01 0.31 (0.18) 3.61E-03 7.50E-02
cg06226150 − 1.37 (0.88) 1.12E-01 1.74E-01 0.21 (0.14) 4.51E-03 1.24E-01
cg23161492 − 5.41 (1.57) 5.18E-04 4.04E-03 0.68 (0.24) 9.43E-03 3.95E-03
cg09022230 0.73 (1.23) 5.42E-01 6.21E-01 0.15 (0.19) 9.65E-03 4.52E-01
cg19572487 − 4.19 (1.44) 2.96E-03 1.19E-02 0.60 (0.20) 1.07E-02 2.64E-03
cg03991871 − 5.59 (2.37) 1.63E-02 3.74E-02 0.40 (0.36) 1.25E-02 2.48E-01
cg14580211 − 0.43 (1.40) 7.46E-01 7.86E-01 0.43 (0.21) 1.48E-02 3.25E-02
cg15187398 − 1.28 (1.31) 3.10E-01 3.90E-01 0.15 (0.20) 1.60E-02 4.27E-01
cg10750182 − 0.64 (0.67) 3.20E-01 3.90E-01 0.15 (0.10) 2.53E-02 1.05E-01
cg25949550 − 2.80 (1.25) 2.24E-02 4.86E-02 0.59 (0.20) 3.19E-02 2.17E-03
cg05284742 − 0.49 (1.13) 6.58E-01 7.13E-01 0.21 (0.16) 3.24E-02 1.81E-01
cg23931381 0.71 (1.50) 6.03E-01 6.72E-01 0.20 (0.23) 3.40E-02 4.26E-01
cg26271591 − 0.44 (1.74) 7.87E-01 8.02E-01 0.34 (0.26) 4.72E-02 1.77E-01
cg03646329 − 2.47 (1.98) 1.99E-01 2.65E-01 0.63 (0.30) 4.72E-02 3.08E-02
cg21733098 − 1.78 (2.49) 4.55E-01 5.38E-01 − 0.03 (0.38) 4.72E-02 9.23E-01
  1. Regression coefficients were reported as being multiplied by 100, as well as for standard errors