Table 1 39 CpGs at which methylation was found to be associated with smoking status with FDR < 0.05
From: Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study
CpG | CHR | Loci | Methylation level, mean (standard deviation) | P | FDR | ||
|---|---|---|---|---|---|---|---|
Never smokers | Former smokers | Current smokers | |||||
cg05575921 | 5 | AHRR | 0.82 (0.04) | 0.79 (0.05) | 0.69 (0.08) | 2.69E-41 | 1.11E-35 |
cg05951221 | 2 | 2q37.1 | 0.48 (0.05) | 0.44 (0.06) | 0.38 (0.06) | 1.01E-28 | 2.08E-23 |
cg01940273 | 2 | 2q37.1 | 0.69 (0.04) | 0.66 (0.05) | 0.60 (0.05) | 1.03E-25 | 1.41E-20 |
cg03636183 | 19 | F2RL3 | 0.72 (0.04) | 0.70 (0.05) | 0.64 (0.06) | 2.86E-22 | 2.94E-17 |
cg06126421 | 6 | 6p21.33 | 0.79 (0.05) | 0.76 (0.06) | 0.72 (0.06) | 1.22E-17 | 1.00E-12 |
cg26703534 | 5 | AHRR | 0.68 (0.03) | 0.69 (0.03) | 0.64 (0.03) | 4.44E-16 | 3.04E-11 |
cg21161138 | 5 | AHRR | 0.77 (0.03) | 0.76 (0.04) | 0.72 (0.05) | 1.21E-14 | 7.11E-10 |
cg11660018 | 11 | PRSS23 | 0.59 (0.04) | 0.57 (0.04) | 0.54 (0.04) | 8.59E-12 | 4.42E-07 |
cg09935388 | 1 | GFI1 | 0.82 (0.05) | 0.81 (0.05) | 0.75 (0.07) | 5.90E-11 | 2.70E-06 |
cg25648203 | 5 | AHRR | 0.84 (0.02) | 0.83 (0.02) | 0.81 (0.03) | 1.63E-10 | 6.71E-06 |
cg19859270 | 3 | GPR15 | 0.93 (0.01) | 0.93 (0.01) | 0.92 (0.01) | 2.77E-10 | 1.04E-05 |
cg03329539 | 2 | 2q37.1 | 0.47 (0.05) | 0.46 (0.05) | 0.42 (0.04) | 5.04E-10 | 1.73E-05 |
cg24859433 | 6 | 6p21.33 | 0.88 (0.02) | 0.88 (0.02) | 0.86 (0.02) | 6.02E-10 | 1.85E-05 |
cg14753356 | 6 | 6p21.33 | 0.47 (0.06) | 0.45 (0.06) | 0.43 (0.05) | 6.28E-10 | 1.85E-05 |
cg07339236 | 20 | ATP9A | 0.17 (0.04) | 0.16 (0.04) | 0.13 (0.03) | 3.68E-09 | 1.01E-04 |
cg04885881 | 1 | 1p36.22 | 0.48 (0.05) | 0.47 (0.05) | 0.44 (0.05) | 4.46E-09 | 1.15E-04 |
cg23916896 | 5 | AHRR | 0.29 (0.07) | 0.27 (0.06) | 0.23 (0.06) | 1.01E-08 | 2.43E-04 |
cg14817490 | 5 | AHRR | 0.30 (0.04) | 0.03 (0.04) | 0.26 (0.04) | 1.37E-08 | 3.14E-04 |
cg11902777 | 5 | AHRR | 0.08 (0.02) | 0.08 (0.02) | 0.06 (0.02) | 4.01E-08 | 8.55E-04 |
cg21611682 | 11 | LRP5 | 0.61 (0.03) | 0.60 (0.03) | 0.58 (0.03) | 4.16E-08 | 8.55E-04 |
cg01692968 | 9 | 9q31.1 | 0.41 (0.05) | 0.39 (0.05) | 0.38 (0.05) | 5.57E-08 | 1.09E-03 |
cg08709672 | 1 | AVPR1B | 0.60 (0.03) | 0.59 (0.03) | 0.57 (0.03) | 6.54E-08 | 1.22E-03 |
cg07826859 | 7 | MYO1G | 0.66 (0.04) | 0.65 (0.04) | 0.63 (0.03) | 1.14E-07 | 2.04E-03 |
cg25189904 | 1 | GNG12 | 0.53 (0.06) | 0.51 (0.07) | 0.47 (0.07) | 1.36E-07 | 2.33E-03 |
cg17287155 | 5 | AHRR | 0.86 (0.03) | 0.85 (0.03) | 0.84 (0.03) | 2.19E-07 | 3.61E-03 |
cg06226150 | 20 | SLC2A4RG | 0.28 (0.03) | 0.28 (0.02) | 0.26 (0.02) | 2.85E-07 | 4.51E-03 |
cg23161492 | 15 | ANPEP | 0.30 (0.05) | 0.29 (0.05) | 0.26 (0.05) | 6.19E-07 | 9.43E-03 |
cg09022230 | 7 | TNRC18 | 0.76 (0.04) | 0.75 (0.04) | 0.73 (0.04) | 6.57E-07 | 9.65E-03 |
cg19572487 | 17 | RARA | 0.63 (0.05) | 0.61 (0.05) | 0.60 (0.06) | 7.54E-07 | 1.07E-02 |
cg03991871 | 5 | AHRR | 0.89 (0.03) | 0.89 (0.03) | 0.86 (0.04) | 9.13E-07 | 1.25E-02 |
cg14580211 | 5 | C5orf62 | 0.76 (0.04) | 0.75 (0.04) | 0.73 (0.04) | 1.12E-06 | 1.48E-02 |
cg15187398 | 19 | MOBKL2A | 0.53 (0.05) | 0.51 (0.05) | 0.49 (0.04) | 1.25E-06 | 1.60E-02 |
cg10750182 | 10 | C10orf105 | 0.62 (0.03) | 0.62 (0.03) | 0.60 (0.03) | 2.03E-06 | 2.53E-02 |
cg25949550 | 7 | CNTNAP2 | 0.13 (0.02) | 0.13 (0.02) | 0.12 (0.02) | 2.64E-06 | 3.19E-02 |
cg05284742 | 14 | ITPK1 | 0.78 (0.03) | 0.77 (0.03) | 0.76 (0.04) | 2.76E-06 | 3.24E-02 |
cg23931381 | 19 | ARRDC2 | 0.89 (0.02) | 0.88 (0.02) | 0.87 (0.02) | 2.98E-06 | 3.40E-02 |
cg26271591 | 2 | NFE2L2 | 0.46 (0.06) | 0.45 (0.06) | 0.41 (0.06) | 4.40E-06 | 4.72E-02 |
cg03646329 | 13 | LPAR6 | 0.82 (0.04) | 0.81 (0.05) | 0.79 (0.05) | 4.47E-06 | 4.72E-02 |
cg21733098 | 12 | 12q24.32 | 0.76 (0.06) | 0.75 (0.07) | 0.72 (0.06) | 4.47E-06 | 4.72E-02 |