Skip to main content

Table 1 39 CpGs at which methylation was found to be associated with smoking status with FDR < 0.05

From: Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study

CpG CHR Loci Methylation level, mean (standard deviation) P FDR
Never smokers Former smokers Current smokers
cg05575921 5 AHRR 0.82 (0.04) 0.79 (0.05) 0.69 (0.08) 2.69E-41 1.11E-35
cg05951221 2 2q37.1 0.48 (0.05) 0.44 (0.06) 0.38 (0.06) 1.01E-28 2.08E-23
cg01940273 2 2q37.1 0.69 (0.04) 0.66 (0.05) 0.60 (0.05) 1.03E-25 1.41E-20
cg03636183 19 F2RL3 0.72 (0.04) 0.70 (0.05) 0.64 (0.06) 2.86E-22 2.94E-17
cg06126421 6 6p21.33 0.79 (0.05) 0.76 (0.06) 0.72 (0.06) 1.22E-17 1.00E-12
cg26703534 5 AHRR 0.68 (0.03) 0.69 (0.03) 0.64 (0.03) 4.44E-16 3.04E-11
cg21161138 5 AHRR 0.77 (0.03) 0.76 (0.04) 0.72 (0.05) 1.21E-14 7.11E-10
cg11660018 11 PRSS23 0.59 (0.04) 0.57 (0.04) 0.54 (0.04) 8.59E-12 4.42E-07
cg09935388 1 GFI1 0.82 (0.05) 0.81 (0.05) 0.75 (0.07) 5.90E-11 2.70E-06
cg25648203 5 AHRR 0.84 (0.02) 0.83 (0.02) 0.81 (0.03) 1.63E-10 6.71E-06
cg19859270 3 GPR15 0.93 (0.01) 0.93 (0.01) 0.92 (0.01) 2.77E-10 1.04E-05
cg03329539 2 2q37.1 0.47 (0.05) 0.46 (0.05) 0.42 (0.04) 5.04E-10 1.73E-05
cg24859433 6 6p21.33 0.88 (0.02) 0.88 (0.02) 0.86 (0.02) 6.02E-10 1.85E-05
cg14753356 6 6p21.33 0.47 (0.06) 0.45 (0.06) 0.43 (0.05) 6.28E-10 1.85E-05
cg07339236 20 ATP9A 0.17 (0.04) 0.16 (0.04) 0.13 (0.03) 3.68E-09 1.01E-04
cg04885881 1 1p36.22 0.48 (0.05) 0.47 (0.05) 0.44 (0.05) 4.46E-09 1.15E-04
cg23916896 5 AHRR 0.29 (0.07) 0.27 (0.06) 0.23 (0.06) 1.01E-08 2.43E-04
cg14817490 5 AHRR 0.30 (0.04) 0.03 (0.04) 0.26 (0.04) 1.37E-08 3.14E-04
cg11902777 5 AHRR 0.08 (0.02) 0.08 (0.02) 0.06 (0.02) 4.01E-08 8.55E-04
cg21611682 11 LRP5 0.61 (0.03) 0.60 (0.03) 0.58 (0.03) 4.16E-08 8.55E-04
cg01692968 9 9q31.1 0.41 (0.05) 0.39 (0.05) 0.38 (0.05) 5.57E-08 1.09E-03
cg08709672 1 AVPR1B 0.60 (0.03) 0.59 (0.03) 0.57 (0.03) 6.54E-08 1.22E-03
cg07826859 7 MYO1G 0.66 (0.04) 0.65 (0.04) 0.63 (0.03) 1.14E-07 2.04E-03
cg25189904 1 GNG12 0.53 (0.06) 0.51 (0.07) 0.47 (0.07) 1.36E-07 2.33E-03
cg17287155 5 AHRR 0.86 (0.03) 0.85 (0.03) 0.84 (0.03) 2.19E-07 3.61E-03
cg06226150 20 SLC2A4RG 0.28 (0.03) 0.28 (0.02) 0.26 (0.02) 2.85E-07 4.51E-03
cg23161492 15 ANPEP 0.30 (0.05) 0.29 (0.05) 0.26 (0.05) 6.19E-07 9.43E-03
cg09022230 7 TNRC18 0.76 (0.04) 0.75 (0.04) 0.73 (0.04) 6.57E-07 9.65E-03
cg19572487 17 RARA 0.63 (0.05) 0.61 (0.05) 0.60 (0.06) 7.54E-07 1.07E-02
cg03991871 5 AHRR 0.89 (0.03) 0.89 (0.03) 0.86 (0.04) 9.13E-07 1.25E-02
cg14580211 5 C5orf62 0.76 (0.04) 0.75 (0.04) 0.73 (0.04) 1.12E-06 1.48E-02
cg15187398 19 MOBKL2A 0.53 (0.05) 0.51 (0.05) 0.49 (0.04) 1.25E-06 1.60E-02
cg10750182 10 C10orf105 0.62 (0.03) 0.62 (0.03) 0.60 (0.03) 2.03E-06 2.53E-02
cg25949550 7 CNTNAP2 0.13 (0.02) 0.13 (0.02) 0.12 (0.02) 2.64E-06 3.19E-02
cg05284742 14 ITPK1 0.78 (0.03) 0.77 (0.03) 0.76 (0.04) 2.76E-06 3.24E-02
cg23931381 19 ARRDC2 0.89 (0.02) 0.88 (0.02) 0.87 (0.02) 2.98E-06 3.40E-02
cg26271591 2 NFE2L2 0.46 (0.06) 0.45 (0.06) 0.41 (0.06) 4.40E-06 4.72E-02
cg03646329 13 LPAR6 0.82 (0.04) 0.81 (0.05) 0.79 (0.05) 4.47E-06 4.72E-02
cg21733098 12 12q24.32 0.76 (0.06) 0.75 (0.07) 0.72 (0.06) 4.47E-06 4.72E-02