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Table 2 Hypermethylated genes by MethylMix criteria unique to patients who survived less than 2 years after cystectomy (references listed in Additional file 3: Table S3)

From: Integrative analysis of the epigenetic basis of muscle-invasive urothelial carcinoma

Gene symbol Gene name Chromosome Associated with aggressive behavior in cancer Tumor suppressor/hypermethylated in cancer Altered pathways Cancer types
CXCL6 C-X-C motif chemokine ligand 6 4q13.3   [44]   Ovarian cancer [44]
ZFP42 ZFP42 zinc finger protein 4q35.2    Sox2, NOTCH/STAT3 [45] Human embryonic stem cell marker [45]
PITX1 Paired-like homeodomain 1 5q31.1 [46, 47]    Kidney cancer [46]
Hepatocellular cancer [47]
RSPH9 Radial spoke head 9 homolog 6p21.1 [48] [49]   Bladder cancer [50]
Hepatocellular cancer
HIST1H3E Histone cluster 1 H3 family member e 6p22.2 [51]    Glioma [51]
SP8 Sp8 transcription factor 7p21.2    Wnt/B-Catenin [52]  
TAC1 Tachykinin precursor 1 7q21-q22 [46, 53, 54] [55]   Head/neck cancer [53]
Colorectal cancer [54, 55]
Esophageal cancer [46]
PON3 Paraoxonase 3 7q21.3   [56, 57]   Bladder cancer [56]
Prostate cancer [57]
ABF1 Musculin (activated B cell factor 1) 8q13.3   [58]   Lymphoma [58]
FOXE1 Forkhead box E1 9q22 [59] [60] Estrogen signaling [61] Colorectal carcinoma [59]
Cutanous squamous cell cancer [60]
Thyroid cancer [62]
CCDC67 Deuterosome assembly protein 1 11q21 [63] [64]   Thyroid carcinoma [63]
Gastric carcinoma [64]
ALX1 ALX homeobox 1 12q21.31 [65] [66] Snail [67] Breast cancer [66]
Non-small cell lung cancer [65]
Ovarian cancer [67]
SLC6A15 Solute carrier family 6 member 15 12q21.31   [68, 69]   Colorectal carcinoma [68, 69]
EID3 EP300 interacting inhibitor of differentiation 3 12q23.3   [70]   Colorectal cancer [70]
NKX2-8 NK2 homeobox 8 14q13.3 [71] [72, 73] NF-KB [72], MEK/ERK [71] Bladder cancer [71]
Cervical cancer [73]
Esopheageal cancer [72]
DIO3 Deiodinase, iodothyronine type III 14q32   [74, 75]   Lung cancer [74]
Hematologic malignancies [75]
FOXC2 Forkhead box C2 16q24.1   [76] MPK/AKT Breast cancer [76]
HSPB6 Heat shock protein family B (small) member 6 19q13.13 [77]    Melanoma [77]
ZNF382 Zinc finger protein 382 19q13.13   [78] NF-kB [79] Esophageal cancer [78]