Fig. 2

Of the 220 statistically significant genes for patients who died within 2 years, 32% were hypermethylated. Of the 266 statistically significant genes for patients who survived more than 2 years after cystectomy, 26% were hypermethylated and the remainder of the genes were hypomethylated. For both hypermethylated and hypomethylated genes, the majority of genes were shared by the better and worse prognosis groups. However, there were some genes with unique methylation status between the two groups, and there were more genes uniquely hypermethylated in the group that did not survive 2 years compared with the group that survived at least 2 years (p = 0.02). Identities of all genes significant by MethylMix are included in Additional file 1: Table S1