Fig. 6From: Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemmaTF: a balance between activator and repressor. The switch between the activator role or the repressor role of a TF, as that is found in DNMT-including complexes to specificallly methylate some DNA sequences could be explained by different hypothesis: (i) a modulation of the TF/DNMT versus free TF ratio [157, 161], (ii) the stabilization of the TF/DNMT interaction by another co-repressor (e.g., HMTs, HDACs) [149,150,151,152], and (iii) post-translation modifications of TF in favor of DNMT/TF interaction; a genetic (fusion protein) or 3D structure modification of the TF in favor of DNMT/TF interaction [49, 145,146,147]Back to article page