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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma

Fig. 6

TF: a balance between activator and repressor. The switch between the activator role or the repressor role of a TF, as that is found in DNMT-including complexes to specificallly methylate some DNA sequences could be explained by different hypothesis: (i) a modulation of the TF/DNMT versus free TF ratio [157, 161], (ii) the stabilization of the TF/DNMT interaction by another co-repressor (e.g., HMTs, HDACs) [149,150,151,152], and (iii) post-translation modifications of TF in favor of DNMT/TF interaction; a genetic (fusion protein) or 3D structure modification of the TF in favor of DNMT/TF interaction [49, 145,146,147]

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