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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma

Fig. 5

Putative TF/DNMT interactions. In vitro experiments with transcriptional factors arrays and recombinant DNMT1, DNMT3A, DNMT3B or DNMT3L revealed that some TFs can potentially interact with several or only one DNMT. White: TFs interacting only with DNMT3L; red: TFs interacting only with DNMT1; yellow: TFs interacting only with DNMT3A; blue: TFs interacting only with DNMT3B; green (blue+yellow): TFs interacting with both DNMT3A and DNMT3B; orange (red + yellow): TFs interacting with both DNMT3A and DNMT1; purple (red + blue): TFs interacting with both DNMT3B and DNMT1; light red: TFs interacting with both DNMT1 and DNMT3L; brown (red + blue + yellow): TFs interacting with DNMT1, DNMT3A and DNMT3B; light yellow (yellow + white): TFs interacting with both DNMT3A and DNMT3L; light blue (blue + white): TFs interacting with both DNMT3B and DNMT3L; light green (green + white): TFs interacting with DNMT3A, DNMT3B and DNMT3L; light orange (orange + white): TFs interacting with DNMT1, DNMT3A and DNMT3L; light purple (purple + white): TFs interacting with DNMT1, DNMT3BDNMT3L; light brown (brown + white): TFs interacting with all DNMTs. Adapted from [140, 156, 163]

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