Fig. 4
From: Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
Illustration of the role different DNMT-including complexes in the maintaining DNA methylation. Left: The canonical unspecific DNMT1/UHRF1/PCNA complex processed the maintaining of DNA methylation of most of the CpGs. A cooperation with specific DNMT-including complexes, as illustrated by the SP1/DNMT1 interaction catalyzed the methylation of CpGs on particular loci (e.g., SP1 response elements) which were not methylated by the DNMT1/UHRF1/PCNA complex [40]. Up right: DNA deamination is repaired by a cooperation between the DNA repair machinery (MMR) and DNMT1 [119]. Bottom right: in absence of MIZ, cMYC binds to its response element and activate the expression of the p21 gene. In presence of MIZ, the ternary complex MIZ/cMYC/DNMT3A repressed the p21 gene in a DNA methylation manner [155, 156]