Fig. 3
From: Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
Examples of cooperation between DNA methylation machineries and proteins regulating post-translational modifications of histones. Left: Silencing of a DNA region following DNA replication. Addition of the repressive H3K9me3 mark, removal of H3 acetylation (Ac) and methylation of the new DNA strand is catalyzed by the DNMT1/UHRF1/PCNA/G9a/HDAC1 complex. Right: de novo methylation of a DNA region of heterochromatin (e.g., major satellites). The addition of the H3K9me3 repressive mark by SUV39H1 is read by HP1 and that further induces the recruitment of DNMT3A and/or DNMT3B for de novo methylation of both strands of DNA. Black circles: 5mC; white circles: C. Parental strand: blue; new synthetized strand: orange