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Table 3 Frequency of individuals showing upregulation in all three genes forming the SETDB1-DNMT3a-HDAC1 complex, which interacts with Tat

From: Expression profiling of chromatin-modifying enzymes and global DNA methylation in CD4+ T cells from patients with chronic HIV infection at different HIV control and progression states

Type of patient

SEDTB1 + DNMT3A + HDAC1 complex

 

Upregulated

p value

HIV negative (n = 32)

 

5 (16%)

< 0.001

HIV positive

Noncontroller (n = 26)

8 (31%)

cART recipient (n = 25)

19 (76%)

HIV-controller(n = 34)

11(32%)

  1. Due to missing values, only patients with expression values for SEDTB1, DNMT3A, and HDAC1 were included in this analysis (n = 117). P value indicates differences between the cART recipients compared to the other subgroups
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Clinical Epigenetics

ISSN: 1868-7083

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