| |
RBBP8 promoter methylationb
|
|---|
| |
n
a
|
low
|
high
|
p valuec
|
|---|
|
Parameter:
|
|
Gender
|
|
Male
|
259
|
190
|
69
|
0.062
|
|
Female
|
94
|
78
|
16
|
|
Histological tumor grade
|
|
Low grade
|
20
|
19
|
1
|
0.041
|
|
High grade
|
330
|
247
|
83
|
|
Tumor stage
|
|
pT1-pT2
|
109
|
86
|
23
|
0.49
|
|
pT3-pT4
|
216
|
163
|
53
|
|
pN status
|
|
Negative
|
212
|
161
|
51
|
0.866
|
|
Positive
|
112
|
86
|
26
|
|
pM status
|
|
Negative
|
173
|
131
|
42
|
0.138
|
|
Positive
|
7
|
7
|
0
|
|
RBBP8 mRNAd
|
|
Low
|
200
|
124
|
76
|
≤ 0.001
|
|
High
|
200
|
175
|
25
| |
- Significant p values are in italics
- aOnly patients with primary bladder cancer without any neoadjuvant therapy were included
- bBased on TCGA 450K DNA methylation analysis
- cFisher’s exact test
- dRBBP8 mRNA expression was dichotomized at the median expression level
