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Table 2 Clinicopathological parameters in relation to RBBP8 promoter methylation of the BLCA TCGA dataset

From: Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer

  RBBP8 promoter methylationb
  n a low high p valuec
Parameter:
 Gender
  Male 259 190 69 0.062
  Female 94 78 16
 Histological tumor grade
  Low grade 20 19 1 0.041
  High grade 330 247 83
 Tumor stage
  pT1-pT2 109 86 23 0.49
  pT3-pT4 216 163 53
 pN status
  Negative 212 161 51 0.866
  Positive 112 86 26
 pM status
  Negative 173 131 42 0.138
  Positive 7 7 0
RBBP8 mRNAd
  Low 200 124 76 ≤ 0.001
  High 200 175 25  
  1. Significant p values are in italics
  2. aOnly patients with primary bladder cancer without any neoadjuvant therapy were included
  3. bBased on TCGA 450K DNA methylation analysis
  4. cFisher’s exact test
  5. dRBBP8 mRNA expression was dichotomized at the median expression level