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Table 2 Clinicopathological parameters in relation to RBBP8 promoter methylation of the BLCA TCGA dataset

From: Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer

 

RBBP8 promoter methylationb

 

n a

low

high

p valuec

Parameter:

 Gender

  Male

259

190

69

0.062

  Female

94

78

16

 Histological tumor grade

  Low grade

20

19

1

0.041

  High grade

330

247

83

 Tumor stage

  pT1-pT2

109

86

23

0.49

  pT3-pT4

216

163

53

 pN status

  Negative

212

161

51

0.866

  Positive

112

86

26

 pM status

  Negative

173

131

42

0.138

  Positive

7

7

0

 RBBP8 mRNAd

  Low

200

124

76

≤ 0.001

  High

200

175

25

 
  1. Significant p values are in italics
  2. aOnly patients with primary bladder cancer without any neoadjuvant therapy were included
  3. bBased on TCGA 450K DNA methylation analysis
  4. cFisher’s exact test
  5. dRBBP8 mRNA expression was dichotomized at the median expression level