Fig. 1

Discovery analysis of DNAm pattern in promoter regions of DNA damage repair genes across tumor entities. Promoter methylation of DDR genes was present in 32 different tumor entities. The heatmap summarizes the conducted analysis of the Infinium HumanMethylation450 BeadChip data available from the TCGA project (see the “Methods” section for details). Only those genes (CpG groups near TSS (s)) for which at least one tumor entity exhibited a hypermethylation of more than 5% of cases are shown. Fields for which corresponding normal tissues were hypermethylated in more than 15% are not shown (white). Note: The tumor entities ACC, DLBC, KICH, LGG, MESO, OV, SARC, TGCT, UCS, and UVM were included despite missing corresponding normal tissue samples. Fields were clustered hierarchically in both dimensions